RALA (RAS like proto-oncogene A)

2003-02-01  

Identity

HGNC
RALA
LOCATION
7p14.1
LOCUSID
5898
ALIAS
HINCONS,RAL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5898
MIM: 179550
HGNC: 9839
Ensembl: ENSG00000006451

Variants:

dbSNP: 5898
ClinVar: 5898
TCGA: ENSG00000006451
COSMIC: RALA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006451ENST00000005257P11233
ENSG00000006451ENST00000434466H7C3P7
ENSG00000006451ENST00000436179C9JPE8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pancreatic cancerKEGGko05212
Pathways in cancerKEGGhsa05200
Pancreatic cancerKEGGhsa05212
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
p38MAPK eventsREACTOMER-HSA-171007
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382868212024Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.2
382868212024Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.2
368178612023Identification of RALA as a Therapeutic Target and Prognostic Predictor of Osteosarcoma.0
371167042023Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-β1 production.1
368178612023Identification of RALA as a Therapeutic Target and Prognostic Predictor of Osteosarcoma.0
371167042023Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-β1 production.1
347676742022Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma.5
347676742022Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma.5
340097152021Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.7
340965032021RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis.8
341189602021The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer.4
343203412021RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.7
349444582021RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth.0
340097152021Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.7
340965032021RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis.8

Citation

Dessen P

RALA (RAS like proto-oncogene A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42035/gene-fusions-explorer/gene-fusions-explorer/tumors-explorer/