RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit)

2003-02-01 Affiliation

Identity

HGNC

RBBP5

LOCATION

1q32.1

LOCUSID

5929

ALIAS

RBQ3,SWD1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5929
MIM: 600697
HGNC: 9888
Ensembl: ENSG00000117222

Variants:

dbSNP: 5929
ClinVar: 5929
TCGA: ENSG00000117222
COSMIC: RBBP5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000117222	ENST00000264515	Q15291
ENSG00000117222	ENST00000264515	A0A024R9B5
ENSG00000117222	ENST00000367164	Q15291

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Wnt	REACTOME	R-HSA-195721
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Formation of the beta-catenin:TCF transactivating complex	REACTOME	R-HSA-201722
Deactivation of the beta-catenin transactivating complex	REACTOME	R-HSA-3769402
Developmental Biology	REACTOME	R-HSA-1266738
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
PKMTs methylate histone lysines	REACTOME	R-HSA-3214841
Activation of HOX genes during differentiation	REACTOME	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	REACTOME	R-HSA-5617472

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33416179	2021	Long non‑coding RNA AC245100.4 promotes prostate cancer tumorigenesis via the microRNA‑145‑5p/RBBP5 axis.	10
33416179	2021	Long non‑coding RNA AC245100.4 promotes prostate cancer tumorigenesis via the microRNA‑145‑5p/RBBP5 axis.	10
31400120	2019	The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions.	6
31544921	2019	The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex.	8
31400120	2019	The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions.	6
31544921	2019	The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex.	8
29897600	2018	The structure of the RbBP5 β-propeller domain reveals a surface with potential nucleic acid binding sites.	8
30533424	2018	Retinoblastoma Binding Protein 5 Correlates with the Progression in Hepatocellular Carcinoma.	7
29897600	2018	The structure of the RbBP5 β-propeller domain reveals a surface with potential nucleic acid binding sites.	8
30533424	2018	Retinoblastoma Binding Protein 5 Correlates with the Progression in Hepatocellular Carcinoma.	7
28182322	2017	Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex.	10
28182322	2017	Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex.	10
27189701	2016	RBQ3 participates in multiple myeloma cell proliferation, adhesion and chemoresistance.	4
27566588	2016	Role of RbBP5 and H3K4me3 in the vicinity of Snail transcription start site during epithelial-mesenchymal transition in prostate cancer cell.	14
27189701	2016	RBQ3 participates in multiple myeloma cell proliferation, adhesion and chemoresistance.	4

Citation

Dessen P

RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42063