Identity
HGNC
LOCATION
1q31.2
LOCUSID
ALIAS
1R20,BL34,HEL-S-87,IER1,IR20
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5996
MIM: 600323
HGNC: 9991
Ensembl: ENSG00000090104
Variants:
dbSNP: 5996
ClinVar: 5996
TCGA: ENSG00000090104
COSMIC: RGS1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000090104 | ENST00000367459 | Q08116 |
| ENSG00000090104 | ENST00000367459 | A0A024R945 |
| ENSG00000090104 | ENST00000469578 | Q08116 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by GPCR | REACTOME | R-HSA-372790 |
| GPCR downstream signaling | REACTOME | R-HSA-388396 |
| G alpha (i) signalling events | REACTOME | R-HSA-418594 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA172 | GNAI1 | Gene | Pathway | associated | |||
| PA173 | GNAI3 | Gene | Pathway | associated | |||
| PA175 | GNAS | Gene | Pathway | associated | |||
| PA24347 | GNAI2 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37735297 | 2024 | Regulator of G protein signaling-1 regulates immune infiltration and macrophage polarization in clear cell renal cell carcinoma. | 2 |
| 39015025 | 2024 | RGS1 and CREB5 are direct and common transcriptional targets of ZNF384-fusion proteins. | 1 |
| 37735297 | 2024 | Regulator of G protein signaling-1 regulates immune infiltration and macrophage polarization in clear cell renal cell carcinoma. | 2 |
| 39015025 | 2024 | RGS1 and CREB5 are direct and common transcriptional targets of ZNF384-fusion proteins. | 1 |
| 36938729 | 2023 | ScRNA-seq revealed targeting regulator of G protein signaling 1 to mediate regulatory T cells in Hepatocellular carcinoma. | 0 |
| 37073154 | 2023 | ATF3 Modulates the Proliferation, Migration, and Apoptosis of Synovial Fibroblasts after Arthroscopy by Promoting RGS1 Transcription. | 1 |
| 37850953 | 2023 | RGS1 Modulates Autophagic and Metabolic Programs and Is a Critical Mediator of Human Regulatory T Cell Function. | 1 |
| 38264343 | 2023 | Tumor-intrinsic RGS1 potentiates checkpoint blockade response via ATF3-IFNGR1 axis. | 1 |
| 36938729 | 2023 | ScRNA-seq revealed targeting regulator of G protein signaling 1 to mediate regulatory T cells in Hepatocellular carcinoma. | 0 |
| 37073154 | 2023 | ATF3 Modulates the Proliferation, Migration, and Apoptosis of Synovial Fibroblasts after Arthroscopy by Promoting RGS1 Transcription. | 1 |
| 37850953 | 2023 | RGS1 Modulates Autophagic and Metabolic Programs and Is a Critical Mediator of Human Regulatory T Cell Function. | 1 |
| 38264343 | 2023 | Tumor-intrinsic RGS1 potentiates checkpoint blockade response via ATF3-IFNGR1 axis. | 1 |
| 35879796 | 2022 | RGS1 and related genes as potential targets for immunotherapy in cervical cancer: computational biology and experimental validation. | 17 |
| 36273177 | 2022 | Identification of DNA methylation-regulated differentially expressed genes in RA by integrated analysis of DNA methylation and RNA-Seq data. | 3 |
| 35879796 | 2022 | RGS1 and related genes as potential targets for immunotherapy in cervical cancer: computational biology and experimental validation. | 17 |
Citation
Dessen P
RGS1 (regulator of G protein signaling 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42099/rgs1
