RGS12 (regulator of G protein signaling 12)

2003-12-01  

Identity

HGNC
RGS12
LOCATION
4p16.3
LOCUSID
6002
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6002
MIM: 602512
HGNC: 9994
Ensembl: ENSG00000159788

Variants:

dbSNP: 6002
ClinVar: 6002
TCGA: ENSG00000159788
COSMIC: RGS12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159788ENST00000336727O14924
ENSG00000159788ENST00000338806O14924
ENSG00000159788ENST00000344733O14924
ENSG00000159788ENST00000382788O14924
ENSG00000159788ENST00000514268E9PBG5
ENSG00000159788ENST00000643191A0A2R8YCJ1

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
367972322023RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling.1
367972322023RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling.1
347967762022RGS12 Drives Macrophage Activation and Osteoclastogenesis in Periodontitis.8
349314912022RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment.6
347967762022RGS12 Drives Macrophage Activation and Osteoclastogenesis in Periodontitis.8
349314912022RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment.6
331985572021RGS12 Represses Oral Cancer via the Phosphorylation and SUMOylation of PTEN.11
336862402021RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling.18
331985572021RGS12 Represses Oral Cancer via the Phosphorylation and SUMOylation of PTEN.11
336862402021RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling.18
286110452017RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression.22
286110452017RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression.22
269878132016Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.5
269878132016Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.5
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.7

Citation

Dessen P

RGS12 (regulator of G protein signaling 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42100