RGS3 (regulator of G protein signaling 3)

2003-06-01  

Identity

HGNC
RGS3
LOCATION
9q32
LOCUSID
5998
ALIAS
C2PA,RGP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5998
MIM: 602189
HGNC: 9999
Ensembl: ENSG00000138835

Variants:

dbSNP: 5998
ClinVar: 5998
TCGA: ENSG00000138835
COSMIC: RGS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138835ENST00000317613P49796
ENSG00000138835ENST00000342620H7BXY1
ENSG00000138835ENST00000343817P49796
ENSG00000138835ENST00000343817A0A024R841
ENSG00000138835ENST00000350696P49796
ENSG00000138835ENST00000374134P49796
ENSG00000138835ENST00000374134A0A024R831
ENSG00000138835ENST00000374136Q5VXC0
ENSG00000138835ENST00000374140P49796
ENSG00000138835ENST00000394646P49796
ENSG00000138835ENST00000462143P49796
ENSG00000138835ENST00000462143A0A024R831
ENSG00000138835ENST00000462403P49796
ENSG00000138835ENST00000462403A0A024R833
ENSG00000138835ENST00000467805C9J582
ENSG00000138835ENST00000471324C9J6G2
ENSG00000138835ENST00000496113H7C539
ENSG00000138835ENST00000613049P49796
ENSG00000138835ENST00000613049A0A024R833
ENSG00000138835ENST00000620489A0A087WUY2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
362147672022Pseudogene UBE2MP1 derived transcript enhances in vitro cell proliferation and apoptosis resistance of hepatocellular carcinoma cells through miR-145-5p/RGS3 axis.5
363189842022RGS3 and IL1RAPL1 missense variants implicate defective neurotransmission in early-onset inherited schizophrenias.1
362147672022Pseudogene UBE2MP1 derived transcript enhances in vitro cell proliferation and apoptosis resistance of hepatocellular carcinoma cells through miR-145-5p/RGS3 axis.5
363189842022RGS3 and IL1RAPL1 missense variants implicate defective neurotransmission in early-onset inherited schizophrenias.1
346185662021The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS.26
346185662021The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS.26
329287072020Regulator of G-protein signalling 3 and its regulator microRNA-133a mediate cell proliferation in gastric cancer.6
329287072020Regulator of G-protein signalling 3 and its regulator microRNA-133a mediate cell proliferation in gastric cancer.6
309717212019A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function.3
313647492019MicroRNA‑126‑3p inhibits the proliferation, migration, invasion, and angiogenesis of triple‑negative breast cancer cells by targeting RGS3.17
309717212019A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function.3
313647492019MicroRNA‑126‑3p inhibits the proliferation, migration, invasion, and angiogenesis of triple‑negative breast cancer cells by targeting RGS3.17
300065482018KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development.28
300065482018KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development.28
277549942017Regulator of G-protein signaling 3 targeted by miR-126 correlates with poor prognosis in gastric cancer patients.13

Citation

Dessen P

RGS3 (regulator of G protein signaling 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42103/css/favicon/meetings/