RIN1 (Ras and Rab interactor 1)

2003-02-01  

Identity

HGNC
RIN1
LOCATION
11q13.2
LOCUSID
9610
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9610
MIM: 605965
HGNC: 18749
Ensembl: ENSG00000174791

Variants:

dbSNP: 9610
ClinVar: 9610
TCGA: ENSG00000174791
COSMIC: RIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174791ENST00000311320Q13671
ENSG00000174791ENST00000311320A0A0S2Z4U0
ENSG00000174791ENST00000530056E9PNR2
ENSG00000174791ENST00000530745E9PMB8
ENSG00000174791ENST00000534824H0YCG8
ENSG00000174791ENST00000627248E9PMB8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ras signaling pathwayKEGGhsa04014
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386355692024Expression of RAS and RAB interactor 1 (RIN1) in head and neck tumors at selected hospital in Ghana.0
386355692024Expression of RAS and RAB interactor 1 (RIN1) in head and neck tumors at selected hospital in Ghana.0
330696952020Role of RIN1 on telomerase activity driven by EGF-Ras mediated signaling in breast cancer.3
330696952020Role of RIN1 on telomerase activity driven by EGF-Ras mediated signaling in breast cancer.3
271378932017Prostaglandin E2-Dependent Phosphorylation of RAS Inhibition 1 (RIN1) at Ser 291 and 292 Inhibits Transforming Growth Factor-β-Induced RAS Activation Pathway in Human Synovial Fibroblasts: Role in Cell Migration.3
286124962017RIN1 promotes renal cell carcinoma malignancy by activating EGFR signaling through Rab25.10
271378932017Prostaglandin E2-Dependent Phosphorylation of RAS Inhibition 1 (RIN1) at Ser 291 and 292 Inhibits Transforming Growth Factor-β-Induced RAS Activation Pathway in Human Synovial Fibroblasts: Role in Cell Migration.3
286124962017RIN1 promotes renal cell carcinoma malignancy by activating EGFR signaling through Rab25.10
261948652016Inverse regulation of bridging integrator 1 and BCR-ABL1 in chronic myeloid leukemia.1
271840782016Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion.27
261948652016Inverse regulation of bridging integrator 1 and BCR-ABL1 in chronic myeloid leukemia.1
271840782016Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion.27
219257172012Prognostic significance of RIN1 gene expression in human non-small cell lung cancer.7
222499752012Overexpression of RIN1 associates with tumor grade and progression in patients of bladder urothelial carcinoma.11
225622672012High RIN1 expression is associated with poor prognosis in patients with gastric adenocarcinoma.8

Citation

Dessen P

RIN1 (Ras and Rab interactor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42116/gene-explorer/tumors-explorer/teaching-explorer/