RIT1 (Ras like without CAAX 1)

2003-02-01  

Identity

HGNC
RIT1
LOCATION
1q22
LOCUSID
6016
ALIAS
NS8,RIBB,RIT,ROC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6016
MIM: 609591
HGNC: 10023
Ensembl: ENSG00000143622

Variants:

dbSNP: 6016
ClinVar: 6016
TCGA: ENSG00000143622
COSMIC: RIT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143622ENST00000368322Q92963
ENSG00000143622ENST00000368323Q92963
ENSG00000143622ENST00000461050V9GY29
ENSG00000143622ENST00000539040Q92963
ENSG00000143622ENST00000609492V9GYC3
ENSG00000143622ENST00000651833A0A494C0U3
ENSG00000143622ENST00000651853A0A494C0S1

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to p38 via RIT and RINREACTOMER-HSA-187706

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
354754262023Cardiac features of Noonan syndrome in Japanese patients.2
380174792023RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma.1
354754262023Cardiac features of Noonan syndrome in Japanese patients.2
380174792023RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma.1
352906202022RIT1 Promotes Glioma Proliferation and Invasion via the AKT/ERK/NF-ĸB Signaling Pathway.1
352906202022RIT1 Promotes Glioma Proliferation and Invasion via the AKT/ERK/NF-ĸB Signaling Pathway.1
335171462021The RIT1 C-terminus associates with lipid bilayers via charge complementarity.4
341848242021Expanding the clinical phenotype of RASopathies in 38 Turkish patients, including the rare LZTR1, RAF1, RIT1 variants, and large deletion in NF1.6
343734512021Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer.16
348469182021Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1.5
335171462021The RIT1 C-terminus associates with lipid bilayers via charge complementarity.4
341848242021Expanding the clinical phenotype of RASopathies in 38 Turkish patients, including the rare LZTR1, RAF1, RIT1 variants, and large deletion in NF1.6
343734512021Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer.16
348469182021Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1.5
327668472020The molecular functions of RIT1 and its contribution to human disease.7

Citation

Dessen P

RIT1 (Ras like without CAAX 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42122