RNF4 (ring finger protein 4)

2003-05-01  

Identity

HGNC
LOCATION
4p16.3
LOCUSID
ALIAS
RES4-26,SLX5,SNURF
FUSION GENES

Other Information

Locus ID:

NCBI: 6047
MIM: 602850
HGNC: 10067
Ensembl: ENSG00000063978

Variants:

dbSNP: 6047
ClinVar: 6047
TCGA: ENSG00000063978
COSMIC: RNF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000063978ENST00000314289P78317
ENSG00000063978ENST00000502316D6RA71
ENSG00000063978ENST00000504224D6RJF5
ENSG00000063978ENST00000506706P78317
ENSG00000063978ENST00000507247D6RAD8
ENSG00000063978ENST00000508235H0YAI5
ENSG00000063978ENST00000509258D6RBZ1
ENSG00000063978ENST00000511600P78317
ENSG00000063978ENST00000511859P78317
ENSG00000063978ENST00000513284D6RJ08
ENSG00000063978ENST00000513450D6RBQ7
ENSG00000063978ENST00000513578D6R9E0
ENSG00000063978ENST00000541204P78317

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383403772024RNF4 prevents genomic instability caused by chronic DNA under-replication.1
385303552024RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication.1
383403772024RNF4 prevents genomic instability caused by chronic DNA under-replication.1
385303552024RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication.1
350078362022Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination.2
352369662022RNF4 silencing induces cell growth arrest and DNA damage by promoting nuclear targeting of p62 in hepatocellular carcinoma.2
356221432022PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As(2)O(3) by stabilizing oncoprotein PML-RARα.2
359266592022RNF4 promotes tumorigenesis, therapy resistance of cholangiocarcinoma and affects cell cycle by regulating the ubiquitination degradation of p27kip1 in the nucleus.1
361533212022RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.3
350078362022Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination.2
352369662022RNF4 silencing induces cell growth arrest and DNA damage by promoting nuclear targeting of p62 in hepatocellular carcinoma.2
356221432022PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As(2)O(3) by stabilizing oncoprotein PML-RARα.2
359266592022RNF4 promotes tumorigenesis, therapy resistance of cholangiocarcinoma and affects cell cycle by regulating the ubiquitination degradation of p27kip1 in the nucleus.1
361533212022RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.3
321978372020RNF4-mediated SUMO-targeted ubiquitination relieves PARIS/ZNF746-mediated transcriptional repression.5

Citation

Dessen P

RNF4 (ring finger protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42137/js/gene-explorer/css/template-nav.css