RNF4 (ring finger protein 4)

2003-05-01  

Identity

HGNC
RNF4
LOCATION
4p16.3
LOCUSID
6047
ALIAS
RES4-26,SLX5,SNURF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6047
MIM: 602850
HGNC: 10067
Ensembl: ENSG00000063978

Variants:

dbSNP: 6047
ClinVar: 6047
TCGA: ENSG00000063978
COSMIC: RNF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000063978ENST00000314289P78317
ENSG00000063978ENST00000502316D6RA71
ENSG00000063978ENST00000504224D6RJF5
ENSG00000063978ENST00000506706P78317
ENSG00000063978ENST00000507247D6RAD8
ENSG00000063978ENST00000508235H0YAI5
ENSG00000063978ENST00000509258D6RBZ1
ENSG00000063978ENST00000511600P78317
ENSG00000063978ENST00000511859P78317
ENSG00000063978ENST00000513284D6RJ08
ENSG00000063978ENST00000513450D6RBQ7
ENSG00000063978ENST00000513578D6R9E0
ENSG00000063978ENST00000541204P78317

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383403772024RNF4 prevents genomic instability caused by chronic DNA under-replication.1
385303552024RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication.1
383403772024RNF4 prevents genomic instability caused by chronic DNA under-replication.1
385303552024RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication.1
350078362022Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination.2
352369662022RNF4 silencing induces cell growth arrest and DNA damage by promoting nuclear targeting of p62 in hepatocellular carcinoma.2
356221432022PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As(2)O(3) by stabilizing oncoprotein PML-RARα.2
359266592022RNF4 promotes tumorigenesis, therapy resistance of cholangiocarcinoma and affects cell cycle by regulating the ubiquitination degradation of p27kip1 in the nucleus.1
361533212022RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.3
350078362022Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination.2
352369662022RNF4 silencing induces cell growth arrest and DNA damage by promoting nuclear targeting of p62 in hepatocellular carcinoma.2
356221432022PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As(2)O(3) by stabilizing oncoprotein PML-RARα.2
359266592022RNF4 promotes tumorigenesis, therapy resistance of cholangiocarcinoma and affects cell cycle by regulating the ubiquitination degradation of p27kip1 in the nucleus.1
361533212022RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.3
321978372020RNF4-mediated SUMO-targeted ubiquitination relieves PARIS/ZNF746-mediated transcriptional repression.5

Citation

Dessen P

RNF4 (ring finger protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42137/js/gene-explorer/css/template-nav.css