RORA (RAR related orphan receptor A)

2003-06-01  

Identity

HGNC
RORA
LOCATION
15q22.2
LOCUSID
6095
ALIAS
IDDECA,NR1F1,ROR1,ROR2,ROR3,RZR-ALPHA,RZRA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6095
MIM: 600825
HGNC: 10258
Ensembl: ENSG00000069667

Variants:

dbSNP: 6095
ClinVar: 6095
TCGA: ENSG00000069667
COSMIC: RORA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069667ENST00000261523P35398
ENSG00000069667ENST00000309157A0A0C4DFP5
ENSG00000069667ENST00000335670P35398
ENSG00000069667ENST00000449337A0A0C4DG53
ENSG00000069667ENST00000551975H0YII6
ENSG00000069667ENST00000558904A0A087X2G0
ENSG00000069667ENST00000559343H0YLS5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
RORA activates gene expressionREACTOMER-HSA-1368082
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444987Multiple SclerosisDiseaseClinicalAnnotationassociatedPD31649263
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD19846067
PA449015citalopramChemicalClinicalAnnotationassociatedPD19846067
PA450037interferon beta-1aChemicalClinicalAnnotationassociatedPD31649263

References

Pubmed IDYearTitleCitations
381771862024The single-cell transcriptomic atlas and RORA-mediated 3D epigenomic remodeling in driving corneal epithelial differentiation.0
381771862024The single-cell transcriptomic atlas and RORA-mediated 3D epigenomic remodeling in driving corneal epithelial differentiation.0
368348722023Novel Therapeutic Potential of Retinoid-Related Orphan Receptor α in Cardiovascular Diseases.1
368348722023Novel Therapeutic Potential of Retinoid-Related Orphan Receptor α in Cardiovascular Diseases.1
349953872022Disturbed expression of vitamin D and retinoic acid-related orphan receptors α and γ and of megalin in inflammatory skin diseases.4
356056632022Retinoid orphan nuclear receptor alpha (RORα) suppresses the epithelial-mesenchymal transition (EMT) by directly repressing Snail transcription.4
356360762022RORA polymorphisms are risk factors for allergic rhinitis susceptibility in the Shaanxi Han population.2
358788412022RORA rs8042149 polymorphism moderates the association between PTSD symptom severity and transverse temporal gyrus thickness in Han Chinese adults who lost their only child.2
359348442022ERCC5, HES6 and RORA are potential diagnostic markers of coronary artery disease.1
349953872022Disturbed expression of vitamin D and retinoic acid-related orphan receptors α and γ and of megalin in inflammatory skin diseases.4
356056632022Retinoid orphan nuclear receptor alpha (RORα) suppresses the epithelial-mesenchymal transition (EMT) by directly repressing Snail transcription.4
356360762022RORA polymorphisms are risk factors for allergic rhinitis susceptibility in the Shaanxi Han population.2
358788412022RORA rs8042149 polymorphism moderates the association between PTSD symptom severity and transverse temporal gyrus thickness in Han Chinese adults who lost their only child.2
359348442022ERCC5, HES6 and RORA are potential diagnostic markers of coronary artery disease.1
330916862021Aberrant functional connectivity between the suprachiasmatic nucleus and the superior temporal gyrus: Bridging RORA gene polymorphism with diurnal mood variation in major depressive disorder.5

Citation

Dessen P

RORA (RAR related orphan receptor A)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42142