RPL27 (ribosomal protein L27)

2003-08-01  

Identity

HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
DBA16,L27
FUSION GENES

Other Information

Locus ID:

NCBI: 6155
MIM: 607526
HGNC: 10328
Ensembl: ENSG00000131469

Variants:

dbSNP: 6155
ClinVar: 6155
TCGA: ENSG00000131469
COSMIC: RPL27

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131469ENST00000253788P61353
ENSG00000131469ENST00000253788A0A024R1V4
ENSG00000131469ENST00000586277K7ELC7
ENSG00000131469ENST00000588830K7ERY7
ENSG00000131469ENST00000589037P61353
ENSG00000131469ENST00000589037A0A024R1V4
ENSG00000131469ENST00000589913P61353
ENSG00000131469ENST00000589913A0A024R1V4
ENSG00000131469ENST00000590864K7EQQ9

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Ribosome, eukaryotesKEGGhsa_M00177
Ribosome, eukaryotesKEGGM00177
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Eukaryotic Translation TerminationREACTOMER-HSA-72764
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373874462023RPL27 contributes to colorectal cancer proliferation and stemness via PLK1 signaling.3
378128602023Effect of RPL27 knockdown on the proliferation and apoptosis of human liver cancer cells.0
373874462023RPL27 contributes to colorectal cancer proliferation and stemness via PLK1 signaling.3
378128602023Effect of RPL27 knockdown on the proliferation and apoptosis of human liver cancer cells.0
254249022015Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.51
254249022015Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.51

Citation

Dessen P

RPL27 (ribosomal protein L27)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42152/rpl27