RRAS (RAS related)

2003-02-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
R-Ras

Other Information

Locus ID:

NCBI: 6237
MIM: 165090
HGNC: 10447
Ensembl: ENSG00000126458

Variants:

dbSNP: 6237
ClinVar: 6237
TCGA: ENSG00000126458
COSMIC: RRAS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126458ENST00000246792P10301
ENSG00000126458ENST00000246792A0A024QZF2

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Autophagy - animalKEGGko04140
Axon guidanceKEGGko04360
Regulation of actin cytoskeletonKEGGko04810
MAPK signaling pathwayKEGGhsa04010
Autophagy - animalKEGGhsa04140
Axon guidanceKEGGhsa04360
Regulation of actin cytoskeletonKEGGhsa04810
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsREACTOMER-HSA-442755
Post NMDA receptor activation eventsREACTOMER-HSA-438064
CREB phosphorylation through the activation of RasREACTOMER-HSA-442742
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Sema4D in semaphorin signalingREACTOMER-HSA-400685
Sema4D mediated inhibition of cell attachment and migrationREACTOMER-HSA-416550
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionREACTOMER-HSA-399955
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Apelin signaling pathwayKEGGhsa04371
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA24928ARAFGenePathwayassociated
PA25408BRAFGenePathwayassociated
PA30592MAP3K1GenePathwayassociated
PA34183RAF1GenePathwayassociated
PA7360EGFRGenePathwayassociated

References

Pubmed IDYearTitleCitations
383832882024The ancestral type of the R-RAS protein has oncogenic potential.0
383832882024The ancestral type of the R-RAS protein has oncogenic potential.0
369608692023METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS.3
369608692023METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS.3
345308702021R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.6
345308702021R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.6
282639562017SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.59
282639562017SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.59
269936062016Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation.13
272703122016Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer.12
269936062016Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation.13
272703122016Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer.12
254472042015OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.44
258690662015Girdin/GIV regulates transendothelial permeability by controlling VE-cadherin trafficking through the small GTPase, R-Ras.13
263813332015miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways.30

Citation

Dessen P

RRAS (RAS related)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42172/tumors-explorer/css/haematological-explorer/