RUNX3 (RUNX family transcription factor 3)

2003-02-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
AML2,CBFA3,PEBP2aC
FUSION GENES

Other Information

Locus ID:

NCBI: 864
MIM: 600210
HGNC: 10473
Ensembl: ENSG00000020633

Variants:

dbSNP: 864
ClinVar: 864
TCGA: ENSG00000020633
COSMIC: RUNX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000020633ENST00000308873Q13761
ENSG00000020633ENST00000338888Q13761
ENSG00000020633ENST00000338888A0A024RAH4
ENSG00000020633ENST00000399916Q13761
ENSG00000020633ENST00000399916A0A024RAH4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380096482024Differential Runx3, Eomes, and T-bet expression subdivides MS-associated CD4(+) T cells with brain-homing capacity.1
381976312024RUNX3 inhibits KSHV lytic replication by binding to the viral genome and repressing transcription.0
382407522024Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer.0
384246322024Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in lung adenocarcinoma.0
387048302024Downregulation of lncRNA MIR17HG reduced tumorigenicity and Treg-mediated immune escape of non-small-cell lung cancer cells through targeting the miR-17-5p/RUNX3 axis.0
389132812024RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4 expression.0
380096482024Differential Runx3, Eomes, and T-bet expression subdivides MS-associated CD4(+) T cells with brain-homing capacity.1
381976312024RUNX3 inhibits KSHV lytic replication by binding to the viral genome and repressing transcription.0
382407522024Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer.0
384246322024Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in lung adenocarcinoma.0
387048302024Downregulation of lncRNA MIR17HG reduced tumorigenicity and Treg-mediated immune escape of non-small-cell lung cancer cells through targeting the miR-17-5p/RUNX3 axis.0
389132812024RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4 expression.0
365964032023Genetically encoded Runx3 and CD4(+) intestinal epithelial lymphocyte deficiencies link SKG mouse and human predisposition to spondyloarthropathy.1
366270062023Increased transcription of hsa_circ_0000644 upon RUNX family transcription factor 3 downregulation participates in the malignant development of bladder cancer.1
367595722023Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis.4

Citation

Dessen P

RUNX3 (RUNX family transcription factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42184/css/js/lib/favicon/favicon-32x32.png