RUNX3 (RUNX family transcription factor 3)

2003-02-01  

Identity

HGNC
RUNX3
LOCATION
1p36.11
LOCUSID
864
ALIAS
AML2,CBFA3,PEBP2aC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 864
MIM: 600210
HGNC: 10473
Ensembl: ENSG00000020633

Variants:

dbSNP: 864
ClinVar: 864
TCGA: ENSG00000020633
COSMIC: RUNX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000020633ENST00000308873Q13761
ENSG00000020633ENST00000338888Q13761
ENSG00000020633ENST00000338888A0A024RAH4
ENSG00000020633ENST00000399916Q13761
ENSG00000020633ENST00000399916A0A024RAH4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380096482024Differential Runx3, Eomes, and T-bet expression subdivides MS-associated CD4(+) T cells with brain-homing capacity.1
381976312024RUNX3 inhibits KSHV lytic replication by binding to the viral genome and repressing transcription.0
382407522024Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer.0
384246322024Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in lung adenocarcinoma.0
387048302024Downregulation of lncRNA MIR17HG reduced tumorigenicity and Treg-mediated immune escape of non-small-cell lung cancer cells through targeting the miR-17-5p/RUNX3 axis.0
389132812024RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4 expression.0
380096482024Differential Runx3, Eomes, and T-bet expression subdivides MS-associated CD4(+) T cells with brain-homing capacity.1
381976312024RUNX3 inhibits KSHV lytic replication by binding to the viral genome and repressing transcription.0
382407522024Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer.0
384246322024Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in lung adenocarcinoma.0
387048302024Downregulation of lncRNA MIR17HG reduced tumorigenicity and Treg-mediated immune escape of non-small-cell lung cancer cells through targeting the miR-17-5p/RUNX3 axis.0
389132812024RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4 expression.0
365964032023Genetically encoded Runx3 and CD4(+) intestinal epithelial lymphocyte deficiencies link SKG mouse and human predisposition to spondyloarthropathy.1
366270062023Increased transcription of hsa_circ_0000644 upon RUNX family transcription factor 3 downregulation participates in the malignant development of bladder cancer.1
367595722023Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis.4

Citation

Dessen P

RUNX3 (RUNX family transcription factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42184/favicon/tumors-explorer/favicon/manifest.json