SCRIB (scribble planar cell polarity protein)

2003-02-01  

Identity

HGNC
SCRIB
LOCATION
8q24.3
LOCUSID
23513
ALIAS
CRIB1,SCRB1,SCRIB1,Vartul
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23513
MIM: 607733
HGNC: 30377
Ensembl: ENSG00000180900

Variants:

dbSNP: 23513
ClinVar: 23513
TCGA: ENSG00000180900
COSMIC: SCRIB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180900ENST00000320476Q14160
ENSG00000180900ENST00000356994Q14160
ENSG00000180900ENST00000377533Q14160
ENSG00000180900ENST00000526832H0YCG0
ENSG00000180900ENST00000531942H0YDF9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Asymmetric localization of PCP proteinsREACTOMER-HSA-4608870

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
389206382024Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status.0
389206382024Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status.0
364688422023The cell polarity protein Scribble is downregulated by the water channel aquaporin-5 in breast cancer cells.2
366611382023Scribble and E-cadherin cooperate to control symmetric daughter cell positioning by multiple mechanisms.1
372775292023Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.17
375890752023An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.1
364688422023The cell polarity protein Scribble is downregulated by the water channel aquaporin-5 in breast cancer cells.2
366611382023Scribble and E-cadherin cooperate to control symmetric daughter cell positioning by multiple mechanisms.1
372775292023Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.17
375890752023An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.1
352599942022MUC1 and Polarity Markers INADL and SCRIB Identify Salivary Ductal Cells.4
353806882022PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86 Expression, Growth, and Survival.4
355013672022Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer.6
352599942022MUC1 and Polarity Markers INADL and SCRIB Identify Salivary Ductal Cells.4
353806882022PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86 Expression, Growth, and Survival.4

Citation

Dessen P

SCRIB (scribble planar cell polarity protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42218/teaching-explorer/cancer-prone-explorer/css/lib/dataTables.bootstrap.min.css