SEC61G (SEC61 translocon subunit gamma)

2003-06-01  

Identity

HGNC
SEC61G
LOCATION
7p11.2
LOCUSID
23480
ALIAS
SSS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23480
MIM: 609215
HGNC: 18277
Ensembl: ENSG00000132432

Variants:

dbSNP: 23480
ClinVar: 23480
TCGA: ENSG00000132432
COSMIC: SEC61G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132432ENST00000352861P60059
ENSG00000132432ENST00000352861A0A024QYZ0
ENSG00000132432ENST00000395535P60059
ENSG00000132432ENST00000395535A0A024QYZ0
ENSG00000132432ENST00000415949P60059
ENSG00000132432ENST00000415949A0A024QYZ0
ENSG00000132432ENST00000450622P60059
ENSG00000132432ENST00000450622A0A024QYZ0

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Vibrio cholerae infectionKEGGko05110
Protein exportKEGGhsa03060
Vibrio cholerae infectionKEGGhsa05110
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Sec61 complexKEGGhsa_M00401
Sec61 complexKEGGM00401
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
341730142022SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma.5
360929562022SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK Signaling Pathway.2
341730142022SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma.5
360929562022SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK Signaling Pathway.2
338467952021SEC61G is upregulated and required for tumor progression in human kidney cancer.14
340399552021SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.19
345907922021SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma.10
347740142021Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation.9
338467952021SEC61G is upregulated and required for tumor progression in human kidney cancer.14
340399552021SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.19
345907922021SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma.10
347740142021Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation.9
331710602020SEC61G plays an oncogenic role in hepatocellular carcinoma cells.13
331710602020SEC61G plays an oncogenic role in hepatocellular carcinoma cells.13
310943632019Identification of SEC61G as a Novel Prognostic Marker for Predicting Survival and Response to Therapies in Patients with Glioblastoma.27

Citation

Dessen P

SEC61G (SEC61 translocon subunit gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42241/css/cancer-prone-explorer/