Identity
HGNC
LOCATION
7q33
LOCUSID
ALIAS
SEC8,SEC8L1,Sec8p
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 60412
MIM: 608185
HGNC: 30389
Ensembl: ENSG00000131558
Variants:
dbSNP: 60412
ClinVar: 60412
TCGA: ENSG00000131558
COSMIC: EXOC4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000131558 | ENST00000253861 | Q96A65 |
| ENSG00000131558 | ENST00000393161 | Q96A65 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35471457 | 2022 | EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal. | 1 |
| 36180927 | 2022 | Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study. | 1 |
| 35471457 | 2022 | EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal. | 1 |
| 36180927 | 2022 | Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study. | 1 |
| 33498474 | 2021 | LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8. | 1 |
| 33498474 | 2021 | LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8. | 1 |
| 27769780 | 2017 | Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4. | 10 |
| 27769780 | 2017 | Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4. | 10 |
| 26892009 | 2016 | Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells. | 2 |
| 26892009 | 2016 | Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells. | 2 |
| 25725287 | 2015 | Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways. | 7 |
| 26283729 | 2015 | Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. | 8 |
| 25725287 | 2015 | Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways. | 7 |
| 26283729 | 2015 | Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. | 8 |
| 25244576 | 2014 | Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase (JNK)-interacting protein 4 for mitogen-activated protein kinase kinase 4 (MKK4) and suppresses the phosphorylation of MKK4, p38, and JNK, thereby inhibiting apoptosis. | 10 |
Citation
Dessen P
EXOC4 (exocyst complex component 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/42244/exoc4
