EXOC4 (exocyst complex component 4)

2003-12-01  

Identity

HGNC
EXOC4
LOCATION
7q33
LOCUSID
60412
ALIAS
SEC8,SEC8L1,Sec8p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 60412
MIM: 608185
HGNC: 30389
Ensembl: ENSG00000131558

Variants:

dbSNP: 60412
ClinVar: 60412
TCGA: ENSG00000131558
COSMIC: EXOC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131558ENST00000253861Q96A65
ENSG00000131558ENST00000393161Q96A65

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
354714572022EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal.1
361809272022Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study.1
354714572022EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal.1
361809272022Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study.1
334984742021LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8.1
334984742021LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8.1
277697802017Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4.10
277697802017Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4.10
268920092016Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells.2
268920092016Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells.2
257252872015Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways.7
262837292015Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.8
257252872015Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways.7
262837292015Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.8
252445762014Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase (JNK)-interacting protein 4 for mitogen-activated protein kinase kinase 4 (MKK4) and suppresses the phosphorylation of MKK4, p38, and JNK, thereby inhibiting apoptosis.10

Citation

Dessen P

EXOC4 (exocyst complex component 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42244/gene-fusions/gene-fusions-explorer/