SELE (selectin E, endothelial adhesion molecule 1)

2008-05-01 Gregorio Seidita , Giacomo De Leo , Riccardo Alessandro Affiliation

Dipartimento Biopatologie e Metodologie Biomediche, via divisi, 83 - 90133 Palermo, Italy

Identity

HGNC

SELE

LOCATION

1q24.2

IMAGE

LOCUSID

6401

ALIAS

CD62E,ELAM,ELAM1,ESEL,LECAM2

DNA/RNA

Note

Member of the Selectin family. ELAM and CD62E, two of the alternative gene names, have continued to be used in the literature for this gene.

Exons are represented by solid blue rectangles and introns by black lines.The drawing is in scale.

Description

This gene can be found on Chromosome 1 at location 167,958,406-167,969,803. The gene is composed of 14 exons, spanning approximately 12 kb of genomic DNA in the telomere-to-centromere orientation on chromosome region 1q22-1q25. The promoter region is not included.

Transcription

NM_000450 3834 bp mRNA. The sequence is supported by several sequences (cDNA clones) and produces, by alternative splicing, 5 different protein isoforms (6 transcripts). The transcripts differ by truncation of the N-terminus, truncation of the C-terminus, presence or absence of an exon.

Pseudogene

None

Proteins

Description

Selectin E precursor is composed of 610 amino acids (66655 Da). Subcellular location: Membrane; Single-pass type I membrane protein. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues (Sushi domains). E-Selectin belongs to the selectin family of proteins. Amino acids: 610; Molecular Weight: 66655 Dalton. The phosphorylation on Tyr-603 (cytoplasmic domain) is required for the E-selectin-dependent ERK1 / ERK2 activation.

Expression

The endothelial leukocyte adhesion molecule-1 is ubiquitously expressed in normal tissues. SELE is expressed at high level in cytokine-stimulated endothelial cells.

Localisation

Single-pass type I membrane protein.

Function

E-Selectin is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.

Homology

Using pairwise alignment function of ClustalW2, the corresponding sequences from Mus musculus and Rattus norvegicus match with a score of 72 and 73 respectively.

Mutations

Note

Since adhesion molecules such as members of the selectin family participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis, Wenzel et al. (1994) sought DNA polymorphisms in the ELAM1 gene, which appears to be expressed only in activated endothelium. They identified an A-to-C transversion at cDNA nucleotide 561, resulting in an amino acid exchange from serine to arginine at codon 128 (S128R) in the epidermal growth factor-like domain. They found a significantly higher frequency of the mutation in 97 patients aged 50 years or less with angiographically proven severe atherosclerosis (arginine allele frequency, 0.155) compared with an unselected population (arginine allele frequency, 0.088), as well as in 40 patients aged 40 years or less (arginine allele frequency, 0.21). Mutations of the gene may be a risk factor in atherosclerosis. A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).Genomewide linkage and candidate gene-based association studies demonstrated that variation in 3 genes on 1q23 is important in the determination of differences in blood pressure levels: ATP1B1 (182330), RGS5 (603276), and SELE (Takei et al, 2002; 131210). E-selectin S128R polymorphism can functionally affect tumor-endothelial interactions as well as motility and signaling properties of neoplastic cells that may modulate the metastatic phenotype (Alessandro et al, 2007).

Implicated in

Entity name

Recruiting blood leukocytes to the site of inflammation

Note

E-selectin plays an important role in recruiting leukocytes to the site of inflammation. E-selectin is expressed on endothelial cells in response to inflammatory cytokines IL-1 and TNF-alpha (Bevilacqua et al., 1989). Leukocytes in the blood expressing the correct ligand will bind with low affinity to E-selectin, causing the leukocytes to "roll" along the internal surface of the blood vessel as temporary interactions are made and broken. For these reasons the protein encoded by this gene is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining.

Entity name

Coronary artery disease

Note

Risk of acquiring coronary artery disease in patients with type 2 diabetes mellitus increases significantly in the presence of the 128R mutant allele of the E-selectin gene (Abu Amero et al., 2007). Other authors correlated the G98T mutation in the E-selectin gene with a higher risk of premature coronary artery disease (Zheng et al., 2001). Data from other laboratories confirmed the hypothesis that in systemic inflammation altered E-selectin shedding may play a role in arterial damage and implicated this adhesion molecule in atherosclerotic complications in a high-risk condition (Malatino et al., 2007)

Entity name

Colon carcinoma

Note

Transendothelial migration of colon carcinoma cells

Oncogenesis

E-selectin mediates the adhesion of tumor cells to endothelial cells, and this interaction is associated with metastatic dissemination. Alessandro et al.(2007) studied the S128R polymorphism in the E-selectin gene in patients with metastatic colon cancer and its functional significance. Genotyping for S128R polymorphism was performed on 172 cancer patients and on an age-matched control population demonstrated that the R128 allele was more prevalent in the metastatic patients group than in the non metastatic group or normal controls. In vitro, S128R E-selectin transfected Huvec cells, supported increased adhesion as well as increased cellular signalling of T84 cancer cells compared to WT E-selectin and mock transfected Huvec cells. These findings suggest that the E-selectin S128R polymorphism can functionally affect tumor-endothelial interactions as well as motility and signaling properties of neoplastic cells. These interactions may ultimately modulate the metastatic phenotype.

Entity name

Angiogenesis

Note

E-selectin plays an important role in endostatin-mediated antiangiogenesis. E-selectin is required for the antiangiogenic activity of endostatin in vivo and ex vivo, and is sufficient, via a mechanism requiring the E-selectin cytoplasmic domain, to confer endostatin sensitivity in endothelial cells in vitro (Yu et al., 2004).

Article Bibliography

Pubmed ID	Last Year	Title	Authors
17578587	2007	The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease.	Abu-Amero KK et al
7541576	1995	Circulating adhesion molecules during kidney allograft rejection.	Alcalde G et al
17372905	2007	Role of S128R polymorphism of E-selectin in colon metastasis formation.	Alessandro R et al
14984317	2004	Effect of high glucose concentrations on expression of ELAM-1, VCAM-1 and ICAM-1 in HUVEC with and without cytokine activation.	Altannavch TS et al
15083893	2004	E-selectin polymorphism in erythema nodosum secondary to sarcoidosis.	Amoli MM et al
7536194	1995	Modulation of E-selectin structure/function by metal ions. Studies on limited proteolysis and metal ion regeneration.	Anostario M Jr et al
12186696	2002	L and E selectins in acute myeloid leukemia: expression, clinical relevance and relation to patient outcome.	Aref S et al
15784173	2005	Genomic rearrangements on VCAM1, SELE, APEG1and AIF1 loci in atherosclerosis.	Arvanitis DA et al
17452460	2007	HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells.	Bandyopadhyay S et al
2466335	1989	Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins.	Bevilacqua MP et al
11935152	2002	Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes.	Blüher M et al
12940514	2003	Circulating transforming growth factor-beta1, lipoprotein(a) and cellular adhesion molecules in angiographically assessed coronary artery disease.	Bogavac-Stanojevic N et al
17057786	2005	Analysis of Hemicentin-1, hOgg1, and E-selectin single nucleotide polymorphisms in age-related macular degeneration.	Bojanowski CM et al
15666579	2004	Soluble adhesion molecules are not involved in the development of retinopathy in type 2 diabetic patients.	Boulbou MS et al
11929779	2002	Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions.	Boyce JA et al
12673844	2001	Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells.	Brown MD et al
16565092	2006	HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells.	Burdick MM et al
15331359	2005	Flow-conditioned HUVECs support clustered leukocyte adhesion by coexpressing ICAM-1 and E-selectin.	Burns MP et al
14568956	2003	Complement regulatory protein C1 inhibitor binds to selectins and interferes with endothelial-leukocyte adhesion.	Cai S et al
15560890	2004	Extracts from cigarette smoke induce DNA damage and cell adhesion molecule expression through different pathways.	Chen HW et al
10477700	1999	Human immunodeficiency virus-1 (HIV-1)-Tat protein promotes migration of acquired immunodeficiency syndrome-related lymphoma cells and enhances their adhesion to endothelial cells.	Chirivi RG et al
14734737	2004	E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system.	Chong BF et al
16963035	2006	Long-term effects of tibolone on circulating levels of vascular cell adhesion molecules and E-selectin in postmenopausal women.	Cicinelli E et al
1703529	1991	Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1.	Collins T et al
11827962	2002	The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-kappa B-dependent mechanism.	Cota-Gomez A et al
16980970	2006	G-CSF induces E-selectin ligand expression on human myeloid cells.	Dagia NM et al
15009098	2004	Altered tissue expression pattern of cell adhesion molecules, ICAM-1, E-selectin and VCAM-1, in bullous pemphigoid during methotrexate therapy.	Dahlman-Ghozlan K et al
10419878	1999	Loss of endothelial surface expression of E-selectin in a patient with recurrent infections.	DeLisser HM et al
17939599	2007	Ser128Arg E-selectin and Thr715Pro P-selectin polymorphisms and severe preeclampsia.	Derzbach L et al
9269771	1997	Human immunodeficiency virus-1-tat protein induces the cell surface expression of endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in human endothelial cells.	Dhawan S et al
15593054	2004	Circulating levels of soluble adhesion molecules in patients with ANCA-associated vasculitis.	Di Lorenzo G et al
11402070	2001	CD44 is a major E-selectin ligand on human hematopoietic progenitor cells.	Dimitroff CJ et al
11764211	2001	Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations.	El-Magadmi M et al
12698264	2003	Enhanced expression of E-selectin on the vascular endothelium of peripheral nerve in critically ill patients with neuromuscular disorders.	Fenzi F et al
12820726	2001	Tumor cell MUC1 and CD43 are glycosylated differently with sialyl-Lewis a and x epitopes and show variable interactions with E-selectin under physiological flow conditions.	Fernandez-Rodriguez J et al
11776680	2001	Localization and quantification of adhesion molecule expression in the lower uterine segment during premature labor.	Fischer DC et al
16269612	2006	CD43 is a ligand for E-selectin on CLA+ human T cells.	Fuhlbrigge RC et al
12738381	2003	Interactions of the gastrotropic bacterium Helicobacter pylori with the leukocyte-endothelium adhesion molecules, the selectins--a preliminary report.	Galustian C et al
15179350	2004	Ser128Arg gene polymorphism for E-selectin and severity of atherosclerotic arterial disease.	Ghilardi G et al
9128259	1997	Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin.	Goetz DJ et al
16501492	2006	Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin.	Gong R et al
7509040	1994	Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.	Graves BJ et al
15187162	2004	Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils.	Green CE et al
16710414	2006	The DNA sequence and biological annotation of human chromosome 1.	Gregory SG et al
14534081	2004	Stimulation of adhesion molecule expression in human endothelial cells (HUVEC) by adrenomedullin and corticotrophin.	Hagi-Pavli E et al
12086338	2002	Expression of ICAM-1, VCAM-1, E-selectin and TNF-alpha on the endothelium of femoral and iliac arteries in thromboangiitis obliterans.	Halacheva K et al
10391210	1999	Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.	Halushka MK et al
15735663	2005	A functional interaction between ATF7 and TAF12 that is modulated by TAF4.	Hamard PJ et al
16843446	2006	A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia.	Hattori H et al
1689848	1990	Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions.	Hession C et al
12020443	2002	Mononuclear cell adhesion and cell adhesion molecule liberation after X-irradiation of activated endothelial cells in vitro.	Hildebrandt G et al
7523444	1994	Exogenous tat protein activates central nervous system-derived endothelial cells.	Hofman FM et al
7693046	1993	Exogenous tat protein activates human endothelial cells.	Hofman FM et al
11602579	2001	Molecular events in transmembrane signaling via E-selectin. SHP2 association, adaptor protein complex formation and ERK1/2 activation.	Hu Y et al
15299021	2004	Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand binding kinetics.	Huang J et al
15167972	2004	An immunoglobulin agent (IVIG) inhibits NF-kappaB activation in cultured endothelial cells of coronary arteries in vitro.	Ichiyama T et al
16908800	2006	Homozygosity in the single nucleotide polymorphism Ser128Arg in the E-selectin gene associated with recurrent venous thromboembolism.	Jilma B et al
12165498	2002	L-selectin serves as an E-selectin ligand on cultured human T lymphoblasts.	Jutila MA et al
11697721	2001	Day-night variations in blood levels of nitric oxide, T-TFPI, and E-selectin.	Kanabrocki EL et al
16916660	2006	Polymorphism in L-selectin, E-selectin and ICAM-1 genes in Asian Indian pediatric patients with celiac disease.	Kaur G et al
16773720	2006	Expression of E-selectin, integrin beta1 and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance.	Ke JJ et al
12960351	2003	Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma.	Kiely JM et al
12200386	2002	Hydrocortisone reduced in vivo, inflammation-induced slow rolling of leukocytes and their extravasation into human conjunctiva.	Kirveskari J et al
17963163	2007	Soluble cell adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) in patients with early rheumatoid arthritis.	Klimiuk PA et al
11859093	2002	Cutting Edge: Internalization of transduced E-selectin by cultured human endothelial cells: comparison of dermal microvascular and umbilical vein cells and identification of a phosphoserine-type di-leucine motif.	Kluger MS et al
12388172	2003	E-selectin-inducing activity in plasma from type 2 diabetic patients with maculopathy.	Knudsen ST et al
17143564	2007	Periprocedural soluble P- and E-selectin levels fail as predictors of clinical restenosis in patients treated with elective coronary stenting.	Kozinski M et al
12522014	2003	Src and phosphatidylinositol 3-kinase mediate soluble E-selectin-induced angiogenesis.	Kumar P et al
15387376	2004	Adhesion of HT-29 colon carcinoma cells to endothelial cells requires sequential events involving E-selectin and integrin beta4.	Laferrière J et al
15917220	2005	FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.	Lee DK et al
15194470	2004	Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells.	Lee YW et al
8621728	1996	Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin.	Li F et al
16061120	2005	Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China.	Li Y et al
12898464	2003	Relationship between circulating E-selectin, DD genotype of angiotensin-converting-enzyme, and cardiovascular damage in central obese subjects.	Licata G et al
12172576	2002	Down regulation of endothelial adhesion molecules in node positive breast cancer: possible failure of host defence mechanism.	Madhavan M et al
17875185	2007	Circulating E-selectin as a risk marker in patients with end-stage renal disease.	Malatino LS et al
12172318	2002	Soluble cell adhesion molecules in hypertensive concentric left ventricular hypertrophy.	Malmqvist K et al
12499405	2002	An investigation of the interactions of E-selectin with fuco-oligosaccharides of the blood group family.	Martín MJ et al
15076188	2004	The Leu554Phe polymorphism in the E-selectin gene is associated with blood pressure in overweight people.	Marteau JB et al
11882338	2002	Serum levels of adhesion molecules correlate with insulin resistance.	Matsumoto K et al
12788528	2003	Different mechanisms of adhesion molecule expression in human dermal microvascular endothelial cells by xanthoma tissue-mediated and copper-mediated oxidized low density lipoproteins.	Matsumoto M et al
15833936	2005	E-selectin genotypes and risk of type 2 diabetes in women.	Meigs JB et al
15080580	2004	Expression of endothelial protein C receptor and thrombomodulin in human coronary atherosclerotic plaques.	Merlini PA et al
7681016	1993	Modelling the carbohydrate recognition domain of human E-selectin.	Mills A et al
9597096	1997	HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium.	Mrowiec T et al
14988223	2004	Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid.	Nübel T et al
15086468	2004	Endothelial adhesion molecules in glomerular lesions: association with their severity and diversity in lupus models.	Nakatani K et al
17014013	2006	sE-Selectin expression and A561C polymorphism in relation to rheumatoid arthritis clinical activity.	Navarro-Hernández RE et al
7538217	1995	Effects of modified low density lipoprotein and hypoxia on the expression of endothelial leukocyte adhesion molecule-1.	Okada M et al
1701274	1990	ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex.	Phillips ML et al
15304054	2004	Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase.	Piconi L et al
14763917	2004	Body weight and glucose metabolism have a different effect on circulating levels of ICAM-1, E-selectin, and endothelin-1 in humans.	Pontiroli AE et al
11983205	2002	Quantification of the influence of mycophenolic acid on the release of endothelial adhesion molecules.	Raab M et al
17392035	2007	The Ser128Arg polymorphism for E-selectin gene and brucellosis.	Rafiei A et al
12421968	2002	Enhanced recruitment of Th2 and CLA-negative lymphocytes by the S128R polymorphism of E-selectin.	Rao RM et al
11936588	2002	Soluble selectin levels in patients with lung cancer.	Roselli M et al
1375831	1992	Cell-cell contact mechanisms.	Ryan US et al
11847011	2002	Circulating endothelial adhesion molecules (sE-selectin, sVCAM-1 and sICAM-1) during rHuG-CSF-stimulated stem cell mobilization.	Südhoff T et al
10982036	2000	Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort.	Sass C et al
11981814	2002	Contribution of selectin ligands to eosinophil recruitment into the skin of patients with atopic dermatitis.	Satoh T et al
12792758	2003	High serum soluble E-selectin levels are associated with postoperative haematogenic recurrence in esophageal squamous cell carcinoma patients.	Shimada Y et al
17167725	2006	Soluble VCAM-1 and E-selectin in breast cancer: relationship with staging and with the detection of circulating cancer cells.	Silva HC et al
17389327	2007	Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women.	Song Y et al
7694691	1993	Divergent fates of P- and E-selectins after their expression on the plasma membrane.	Subramaniam M et al
12626663	2003	AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent.	Sundell CL et al
16892455	2007	Human soluble E-selectin immunoadhesin inhibits leukemic monocyte adhesion to endothelial cells.	Sung BH et al
17684030	2007	A cholesterol-independent membrane microdomain serves as a functional counter-receptor for E-selectin at the Colo201 cell surface and initiates signalling on E-selectin binding.	Suzuki C et al
11828340	2002	Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy.	Takei T et al
14714557	2003	Increased E-selectin, IL-8 and IL-10 gene expression in human skin after minimal trauma.	Takeuchi F et al
9920928	1999	E-selectin gene expression is induced synergistically with the coexistence of activated classic protein kinase C and signals elicited by interleukin-1beta but not tumor necrosis factor-alpha.	Tamaru M et al
15736116	2005	Soluble E-selectin, leptin, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients.	Taniguchi A et al
15488708	2004	In vivo evidence for close association of CLA expression and E-selectin binding by T cells in the inflamed skin.	Teraki Y et al
16554320	2006	The E-selectin gene polymorphism and carotid atherosclerosis in end-stage renal disease.	Testa A et al
16433632	2006	Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin.	Totani L et al
11948013	2002	17beta-Estradiol inhibits cytokine induction of the human E-selectin promoter.	Tyree CM et al
15254658	2004	Serum levels of soluble E-selectin in colorectal cancer.	Uner A et al
17956423	2007	A novel leptospiral protein increases ICAM-1 and E-selectin expression in human umbilical vein endothelial cells.	Vieira ML et al
17142773	2006	Thiocyanate-dependent induction of endothelial cell adhesion molecule expression by phagocyte peroxidases: a novel HOSCN-specific oxidant mechanism to amplify inflammation.	Wang JG et al
16974056	2006	Impact of selectin gene polymorphisms on rapid progression to end-stage renal disease in patients with IgA nephropathy.	Watanabe Y et al
1694218	1990	Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.	Watson ML et al
8557254	1996	DNA polymorphisms in adhesion molecule genes--a new risk factor for early atherosclerosis.	Wenzel K et al
7533025	1994	E-selectin polymorphism and atherosclerosis: an association study.	Wenzel K et al
11882337	2002	Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians.	Weyer C et al
11404363	2001	Affinity, kinetics, and thermodynamics of E-selectin binding to E-selectin ligand-1.	Wild MK et al
14592840	2004	Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1.	Winkler IG et al
12011765	2002	Blood serum levels of soluble forms of adhesion molecules ICAM-1 (sICAM-1) and selectin E (s-selectin E) in patients with various phases of non-Hodgkin's lymphomas.	Wołowiec D et al
9933738	1999	A PstI polymorphism detects the mutation of serine128 to arginine in CD 62E gene - a risk factor for coronary artery disease.	Ye SQ et al
15515123	2005	Serum E-selectin and erythrocyte membrane Na+K+ ATPase levels in patients with rheumatoid arthritis.	Yildirim K et al
12649084	2003	E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions.	Yoshida M et al
8609175	1996	Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton.	Yoshida M et al
15148373	2004	E-selectin is required for the antiangiogenic activity of endostatin.	Yu Y et al
9024699	1997	L-selectin from human, but not from mouse neutrophils binds directly to E-selectin.	Zöllner O et al
14607629	2002	E-selectin and its ligand-sLeX in the metastasis of hepatocellular carcinoma.	Zhang BH et al
14592723	2003	L-selectin and E-selectin expressed on monocytes mediating Ehrlichia chaffeensis attachment onto host cells.	Zhang JZ et al
11168027	2001	An HphI polymorphism in the E-selectin gene is associated with premature coronary artery disease.	Zheng F et al

Other Information

Locus ID:

NCBI: 6401
MIM: 131210
HGNC: 10718
Ensembl: ENSG00000007908

Variants:

dbSNP: 6401
ClinVar: 6401
TCGA: ENSG00000007908
COSMIC: SELE

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000007908	ENST00000333360	P16581
ENSG00000007908	ENST00000367774	Q5TI72
ENSG00000007908	ENST00000367775	Q5TI75
ENSG00000007908	ENST00000367776	Q5TI73
ENSG00000007908	ENST00000367777	Q5TI74
ENSG00000007908	ENST00000609271	V9GYI4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Malaria	KEGG	ko05144
Malaria	KEGG	hsa05144
African trypanosomiasis	KEGG	ko05143
African trypanosomiasis	KEGG	hsa05143
TNF signaling pathway	KEGG	hsa04668
TNF signaling pathway	KEGG	ko04668
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA128406956	fluorouracil	Chemical	ClinicalAnnotation	associated	PD	24980946
PA131285527	oxaliplatin	Chemical	ClinicalAnnotation	associated	PD	24980946
PA443756	Colonic Neoplasms	Disease	ClinicalAnnotation	associated	PD	24980946
PA448771	capecitabine	Chemical	ClinicalAnnotation	associated	PD	24980946
PA450198	leucovorin	Chemical	ClinicalAnnotation	associated	PD	24980946

References

Pubmed ID	Year	Title	Citations
38243063	2024	PSGL-1 decorated with sialyl Lewis(a/x) promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement.	0
38428409	2024	PDGFRα(+)ITGA11(+) fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.	4
38493006	2024	Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy?	1
38650162	2024	E-selectin is associated with stable angina and myocardial infarction in a sample of Kurdish population.	0
38243063	2024	PSGL-1 decorated with sialyl Lewis(a/x) promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement.	0
38428409	2024	PDGFRα(+)ITGA11(+) fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.	4
38493006	2024	Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy?	1
38650162	2024	E-selectin is associated with stable angina and myocardial infarction in a sample of Kurdish population.	0
33022186	2023	Association of E-Selectin gene polymorphisms and serum E-Selectin level with risk of coronary artery disease in lur population of Iran.	4
35982357	2023	Increased Circulating CD62E(+) Endothelial Extracellular Vesicles Predict Severity and in- Hospital Mortality of COVID-19 Patients.	7
36409296	2023	Plasma levels of E-selectin are associated with retinopathy in sickle cell disease.	2
37903858	2023	E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation.	5
33022186	2023	Association of E-Selectin gene polymorphisms and serum E-Selectin level with risk of coronary artery disease in lur population of Iran.	4
35982357	2023	Increased Circulating CD62E(+) Endothelial Extracellular Vesicles Predict Severity and in- Hospital Mortality of COVID-19 Patients.	7
36409296	2023	Plasma levels of E-selectin are associated with retinopathy in sickle cell disease.	2

Citation

Gregorio Seidita ; Giacomo De Leo ; Riccardo Alessandro

SELE (selectin E, endothelial adhesion molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/42247/sele-(selectin-e-endothelial-adhesion-molecule-1)