Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10512
MIM: 602645
HGNC: 10725
Ensembl: ENSG00000075223
Variants:
dbSNP: 10512
ClinVar: 10512
TCGA: ENSG00000075223
COSMIC: SEMA3C
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Axon guidance | KEGG | ko04360 |
| Axon guidance | KEGG | hsa04360 |
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 22664479 | |
| PA450085 | irinotecan | Chemical | ClinicalAnnotation | associated | PD | 22664479 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38528115 | 2024 | Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer. | 0 |
| 38956074 | 2024 | Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression. | 0 |
| 38528115 | 2024 | Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer. | 0 |
| 38956074 | 2024 | Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression. | 0 |
| 37055018 | 2023 | Semaphorin 3C exacerbates liver fibrosis. | 3 |
| 37080989 | 2023 | Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma. | 5 |
| 37800655 | 2023 | Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells. | 1 |
| 37055018 | 2023 | Semaphorin 3C exacerbates liver fibrosis. | 3 |
| 37080989 | 2023 | Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma. | 5 |
| 37800655 | 2023 | Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells. | 1 |
| 33420365 | 2021 | MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1-cMET signaling. | 36 |
| 33503318 | 2021 | SEMA3C induces androgen synthesis in prostatic stromal cells through paracrine signaling. | 0 |
| 33557656 | 2021 | Effect of semaphorin 3C gene variants in multifactorial Hirschsprung disease. | 2 |
| 33568674 | 2021 | LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C. | 13 |
| 34076780 | 2021 | Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family. | 2 |
Citation
Dessen P
SEMA3C (semaphorin 3C)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/42253/sema3c
