SERPINA3 (serpin family A member 3)

2003-08-01  

Identity

HGNC
SERPINA3
LOCATION
14q32.13
LOCUSID
12
ALIAS
AACT,ACT,GIG24,GIG25
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 12
MIM: 107280
HGNC: 16
Ensembl: ENSG00000196136

Variants:

dbSNP: 12
ClinVar: 12
TCGA: ENSG00000196136
COSMIC: SERPINA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196136ENST00000393078P01011
ENSG00000196136ENST00000393078A0A024R6P0
ENSG00000196136ENST00000393080P01011
ENSG00000196136ENST00000393080A0A024R6P0
ENSG00000196136ENST00000467132P01011
ENSG00000196136ENST00000467132A0A024R6P0
ENSG00000196136ENST00000482740G3V3A0
ENSG00000196136ENST00000555820G3V595
ENSG00000196136ENST00000556968P01011
ENSG00000196136ENST00000621603A0A087WY93

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445218Pancreatic NeoplasmsDiseaseClinicalAnnotationassociatedPD21487324
PA452621antineoplastic agentsChemicalClinicalAnnotationassociatedPD21487324

References

Pubmed IDYearTitleCitations
374542782024LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease.1
377214052024SERPINA3: A novel inflammatory biomarker associated with cerebral small vessel disease burden in ischemic stroke.4
381338762024Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway.0
386470032024Regulation of CNS pathology by Serpina3n/SERPINA3: The knowns and the puzzles.1
374542782024LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease.1
377214052024SERPINA3: A novel inflammatory biomarker associated with cerebral small vessel disease burden in ischemic stroke.4
381338762024Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway.0
386470032024Regulation of CNS pathology by Serpina3n/SERPINA3: The knowns and the puzzles.1
350076922023Association of α-1-Antichymotrypsin Expression with the Development of Conformational Changes of Tau Protein in Alzheimer's Disease Brain.1
368288762023Newly revealed variants of SERPINA3 in generalized pustular psoriasis attenuate inhibition of ACT on cathepsin G.1
374173622023Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF‑κB in lung cancer.0
350076922023Association of α-1-Antichymotrypsin Expression with the Development of Conformational Changes of Tau Protein in Alzheimer's Disease Brain.1
368288762023Newly revealed variants of SERPINA3 in generalized pustular psoriasis attenuate inhibition of ACT on cathepsin G.1
374173622023Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF‑κB in lung cancer.0
354165702022Serpin Signatures in Prion and Alzheimer's Diseases.18

Citation

Dessen P

SERPINA3 (serpin family A member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42263/css/meetings/