SERPINA3 (serpin family A member 3)

2003-08-01  

Identity

HGNC
LOCATION
14q32.13
LOCUSID
ALIAS
AACT,ACT,GIG24,GIG25
FUSION GENES

Other Information

Locus ID:

NCBI: 12
MIM: 107280
HGNC: 16
Ensembl: ENSG00000196136

Variants:

dbSNP: 12
ClinVar: 12
TCGA: ENSG00000196136
COSMIC: SERPINA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196136ENST00000393078P01011
ENSG00000196136ENST00000393078A0A024R6P0
ENSG00000196136ENST00000393080P01011
ENSG00000196136ENST00000393080A0A024R6P0
ENSG00000196136ENST00000467132P01011
ENSG00000196136ENST00000467132A0A024R6P0
ENSG00000196136ENST00000482740G3V3A0
ENSG00000196136ENST00000555820G3V595
ENSG00000196136ENST00000556968P01011
ENSG00000196136ENST00000621603A0A087WY93

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445218Pancreatic NeoplasmsDiseaseClinicalAnnotationassociatedPD21487324
PA452621antineoplastic agentsChemicalClinicalAnnotationassociatedPD21487324

References

Pubmed IDYearTitleCitations
374542782024LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease.1
377214052024SERPINA3: A novel inflammatory biomarker associated with cerebral small vessel disease burden in ischemic stroke.4
381338762024Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway.0
386470032024Regulation of CNS pathology by Serpina3n/SERPINA3: The knowns and the puzzles.1
374542782024LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease.1
377214052024SERPINA3: A novel inflammatory biomarker associated with cerebral small vessel disease burden in ischemic stroke.4
381338762024Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway.0
386470032024Regulation of CNS pathology by Serpina3n/SERPINA3: The knowns and the puzzles.1
350076922023Association of α-1-Antichymotrypsin Expression with the Development of Conformational Changes of Tau Protein in Alzheimer's Disease Brain.1
368288762023Newly revealed variants of SERPINA3 in generalized pustular psoriasis attenuate inhibition of ACT on cathepsin G.1
374173622023Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF‑κB in lung cancer.0
350076922023Association of α-1-Antichymotrypsin Expression with the Development of Conformational Changes of Tau Protein in Alzheimer's Disease Brain.1
368288762023Newly revealed variants of SERPINA3 in generalized pustular psoriasis attenuate inhibition of ACT on cathepsin G.1
374173622023Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF‑κB in lung cancer.0
354165702022Serpin Signatures in Prion and Alzheimer's Diseases.18

Citation

Dessen P

SERPINA3 (serpin family A member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42263/js/favicon/favicon-16x16.png