SERPINB2 (serpin family B member 2)

2003-08-01  

Identity

HGNC
SERPINB2
LOCATION
18q21.33
LOCUSID
5055
ALIAS
HsT1201,PAI,PAI-2,PAI2,PLANH2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5055
MIM: 173390
HGNC: 8584
Ensembl: ENSG00000197632

Variants:

dbSNP: 5055
ClinVar: 5055
TCGA: ENSG00000197632
COSMIC: SERPINB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197632ENST00000299502P05120
ENSG00000197632ENST00000404622E9PDK7
ENSG00000197632ENST00000413956E7EPJ9
ENSG00000197632ENST00000443281E7ERB5
ENSG00000197632ENST00000457692P05120

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Dissolution of Fibrin ClotREACTOMER-HSA-75205

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362514942024miR-450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma.1
387411462024Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility of triple-negative breast cancer cells.0
362514942024miR-450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma.1
387411462024Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility of triple-negative breast cancer cells.0
354067152022A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone.5
354663662022Unveiling a novel serpinB2-tripeptidyl peptidase II signaling axis during senescence.0
364971102022SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells.1
354067152022A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone.5
354663662022Unveiling a novel serpinB2-tripeptidyl peptidase II signaling axis during senescence.0
364971102022SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells.1
324049812021HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells.7
332273152021Plasminogen activator Inhibitor-2 inhibits pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension via PI3K/Akt and ERK signaling.7
333872932021SERPINB2-its regulation and interplay with aryl hydrocarbon receptor.6
340953222021HMSC-Derived Exosome Inhibited Th2 Cell Differentiation via Regulating miR-146a-5p/SERPINB2 Pathway.16
324049812021HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells.7

Citation

Dessen P

SERPINB2 (serpin family B member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42264