Identity
HGNC
LOCATION
1p36.21
LOCUSID
ALIAS
HIAA0929,MINT,RATARS,RBM15C,SHARP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23013
MIM: 613484
HGNC: 17575
Ensembl: ENSG00000065526
Variants:
dbSNP: 23013
ClinVar: 23013
TCGA: ENSG00000065526
COSMIC: SPEN
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000065526 | ENST00000375759 | Q96T58 |
| ENSG00000065526 | ENST00000438066 | F6WRY4 |
| ENSG00000065526 | ENST00000442985 | H0Y5U7 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38164599 | 2024 | Dissection of protein and RNA regions required for SPEN binding to XIST A-repeat RNA. | 0 |
| 38164599 | 2024 | Dissection of protein and RNA regions required for SPEN binding to XIST A-repeat RNA. | 0 |
| 33596411 | 2021 | SPEN haploinsufficiency causes a neurodevelopmental disorder overlapping proximal 1p36 deletion syndrome with an episignature of X chromosomes in females. | 35 |
| 33596411 | 2021 | SPEN haploinsufficiency causes a neurodevelopmental disorder overlapping proximal 1p36 deletion syndrome with an episignature of X chromosomes in females. | 35 |
| 32641685 | 2020 | SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma. | 13 |
| 32641685 | 2020 | SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma. | 13 |
| 28877752 | 2017 | SPEN, a new player in primary cilia formation and cell migration in breast cancer. | 28 |
| 28877752 | 2017 | SPEN, a new player in primary cilia formation and cell migration in breast cancer. | 28 |
| 25381127 | 2015 | The NOTCH pathway is recurrently mutated in diffuse large B-cell lymphoma associated with hepatitis C virus infection. | 33 |
| 26297734 | 2015 | The Estrogen Receptor Cofactor SPEN Functions as a Tumor Suppressor and Candidate Biomarker of Drug Responsiveness in Hormone-Dependent Breast Cancers. | 31 |
| 25381127 | 2015 | The NOTCH pathway is recurrently mutated in diffuse large B-cell lymphoma associated with hepatitis C virus infection. | 33 |
| 26297734 | 2015 | The Estrogen Receptor Cofactor SPEN Functions as a Tumor Suppressor and Candidate Biomarker of Drug Responsiveness in Hormone-Dependent Breast Cancers. | 31 |
| 24268649 | 2014 | Structural insights into the recruitment of SMRT by the corepressor SHARP under phosphorylative regulation. | 15 |
| 24748666 | 2014 | The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA recognition motifs. | 25 |
| 24268649 | 2014 | Structural insights into the recruitment of SMRT by the corepressor SHARP under phosphorylative regulation. | 15 |
Citation
Dessen P
SPEN (spen family transcriptional repressor)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/42285/spen
