SHPRH (SNF2 histone linker PHD RING helicase)

2003-12-01  

Identity

HGNC
SHPRH
LOCATION
6q24.3
LOCUSID
257218
ALIAS
bA545I5.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 257218
MIM: 608048
HGNC: 19336
Ensembl: ENSG00000146414

Variants:

dbSNP: 257218
ClinVar: 257218
TCGA: ENSG00000146414
COSMIC: SHPRH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146414ENST00000275233Q149N8
ENSG00000146414ENST00000367503K4DI94
ENSG00000146414ENST00000367505Q149N8
ENSG00000146414ENST00000417762Q5JT88
ENSG00000146414ENST00000433355H7C2W2
ENSG00000146414ENST00000438092Q149N8
ENSG00000146414ENST00000519632Q149N8
ENSG00000146414ENST00000521977H0YBI0
ENSG00000146414ENST00000629427A0A0D9SFM0

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382828622024A peptide encoded by the circular form of the SHPRH gene induces apoptosis in neuroblastoma cells.0
382828622024A peptide encoded by the circular form of the SHPRH gene induces apoptosis in neuroblastoma cells.0
346069082021KMT2B promotes SHPRH expression to regulate (131)I sensitivity in thyroid carcinoma cells by affecting FYN protein stability.0
346069082021KMT2B promotes SHPRH expression to regulate (131)I sensitivity in thyroid carcinoma cells by affecting FYN protein stability.0
319730932020Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA).13
321921912020The Human RAD5 Homologs, HLTF and SHPRH, Have Separate Functions in DNA Damage Tolerance Dependent on The DNA Lesion Type.6
319730932020Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA).13
321921912020The Human RAD5 Homologs, HLTF and SHPRH, Have Separate Functions in DNA Damage Tolerance Dependent on The DNA Lesion Type.6
311370162019Circular RNA hsa_circ_0001649 inhibits hepatocellular carcinoma progression via multiple miRNAs sponge.46
311370162019Circular RNA hsa_circ_0001649 inhibits hepatocellular carcinoma progression via multiple miRNAs sponge.46
291393352018SHPRH as a new player in ribosomal RNA transcription and its potential role in homeostasis of ribosomal DNA repeats.4
293438482018A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis.362
291393352018SHPRH as a new player in ribosomal RNA transcription and its potential role in homeostasis of ribosomal DNA repeats.4
293438482018A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis.362
284005112017SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner.17

Citation

Dessen P

SHPRH (SNF2 histone linker PHD RING helicase)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42294