SIN3A (SIN3 transcription regulator family member A)

2003-02-01  

Identity

HGNC
SIN3A
LOCATION
15q24.2
LOCUSID
25942
ALIAS
WITKOS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25942
MIM: 607776
HGNC: 19353
Ensembl: ENSG00000169375

Variants:

dbSNP: 25942
ClinVar: 25942
TCGA: ENSG00000169375
COSMIC: SIN3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169375ENST00000360439Q96ST3
ENSG00000169375ENST00000394947Q96ST3
ENSG00000169375ENST00000394949Q96ST3
ENSG00000169375ENST00000562776H3BNZ3
ENSG00000169375ENST00000564778H3BP90
ENSG00000169375ENST00000565264H3BMA2
ENSG00000169375ENST00000567289H3BQL7
ENSG00000169375ENST00000568190H3BT34
ENSG00000169375ENST00000568309H3BQ76
ENSG00000169375ENST00000568431H3BNA0
ENSG00000169375ENST00000570115H3BQ88

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Huntington's diseaseKEGGko05016
Huntington's diseaseKEGGhsa05016
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Thyroid hormone signaling pathwayKEGGhsa04919
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363991322023DNA methylation episignature for Witteveen-Kolk syndrome due to SIN3A haploinsufficiency.2
377488362023Coordination of cross-talk between metabolism and epigenetic regulation by the SIN3 complex.0
363991322023DNA methylation episignature for Witteveen-Kolk syndrome due to SIN3A haploinsufficiency.2
377488362023Coordination of cross-talk between metabolism and epigenetic regulation by the SIN3 complex.0
352479102022Suppression of SIN3A by miR-183 Promotes Breast Cancer Metastasis.2
354067442022The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells.1
352479102022Suppression of SIN3A by miR-183 Promotes Breast Cancer Metastasis.2
354067442022The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells.1
331420422021Witteveen-Kolk syndrome: The first patient from Turkey.2
331513042021HDAC1-Smad3-mSin3A complex is required for Smad3-induced transcriptional inhibition of hepatocyte growth factor receptor in human lung cancers.1
334370322021Comprehensive study of 28 individuals with SIN3A-related disorder underscoring the associated mild cognitive and distinctive facial phenotype.12
336275042021Transcription Repressor Protein ZBTB25 Associates with HDAC1-Sin3a Complex in Mycobacterium tuberculosis-Infected Macrophages, and Its Inhibition Clears Pathogen by Autophagy.5
340780892021Regulation of the Methylation and Expression Levels of the BMPR2 Gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension.29
345866472021miR-138-5p inhibits proliferation and invasion in kidney renal clear cell carcinoma by targeting SINA3 and regulation of the Notch signaling pathway.3
348844562021Structural Insight into the Binding of TGIF1 to SIN3A PAH2 Domain through a C-Terminal Amphipathic Helix.2

Citation

Dessen P

SIN3A (SIN3 transcription regulator family member A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42298/case-report-explorer/js/css/lib/dataTables.bootstrap.min.css