SPDEF (SAM pointed domain containing ETS transcription factor)

2003-08-01  

Identity

HGNC
SPDEF
LOCATION
6p21.31
LOCUSID
25803
ALIAS
PDEF,bA375E1.3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25803
MIM: 608144
HGNC: 17257
Ensembl: ENSG00000124664

Variants:

dbSNP: 25803
ClinVar: 25803
TCGA: ENSG00000124664
COSMIC: SPDEF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124664ENST00000374037O95238
ENSG00000124664ENST00000544425O95238

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
375158782023Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway.2
376339452023SPDEF enhances cancer stem cell-like properties and tumorigenesis through directly promoting GALNT7 transcription in luminal breast cancer.1
379001382023Regulation of SPDEF expression by DNA methylation in advanced prostate cancer.0
375158782023Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway.2
376339452023SPDEF enhances cancer stem cell-like properties and tumorigenesis through directly promoting GALNT7 transcription in luminal breast cancer.1
379001382023Regulation of SPDEF expression by DNA methylation in advanced prostate cancer.0
359514532022The role of SPDEF in cancer: promoter or suppressor.3
359514532022The role of SPDEF in cancer: promoter or suppressor.3
341913902021The subtype-specific molecular function of SPDEF in breast cancer and insights into prognostic significance.5
346671502021SPDEF suppresses head and neck squamous cell carcinoma progression by transcriptionally activating NR4A1.11
341913902021The subtype-specific molecular function of SPDEF in breast cancer and insights into prognostic significance.5
346671502021SPDEF suppresses head and neck squamous cell carcinoma progression by transcriptionally activating NR4A1.11
315966092020Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis.22
332323572020Assessment of mucin-related gene alterations following treatment with rebamipide ophthalmic suspension in Sjögren's syndrome-associated dry eyes.4
315966092020Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis.22

Citation

Dessen P

SPDEF (SAM pointed domain containing ETS transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42372