SPIB (Spi-B transcription factor)

2003-02-01  

Identity

HGNC
SPIB
LOCATION
19q13.33
LOCUSID
6689
ALIAS
SPI-B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6689
MIM: 606802
HGNC: 11242
Ensembl: ENSG00000269404

Variants:

dbSNP: 6689
ClinVar: 6689
TCGA: ENSG00000269404
COSMIC: SPIB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000269404ENST00000270632Q01892
ENSG00000269404ENST00000439922Q01892
ENSG00000269404ENST00000594685M0R2J9
ENSG00000269404ENST00000595883Q01892
ENSG00000269404ENST00000595883A0A024R4I5
ENSG00000269404ENST00000596074M0R037
ENSG00000269404ENST00000597855M0QXA8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386229802024IGSF10 inhibits the metastasis of lung adenocarcinoma via the Spi-B/Integrin-β1 signaling pathway.0
386229802024IGSF10 inhibits the metastasis of lung adenocarcinoma via the Spi-B/Integrin-β1 signaling pathway.0
364001812023Peroxiredoxin2 regulates trophoblast proliferation and migration through SPIB-HDAC2 pathway.1
374526342023SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway.0
364001812023Peroxiredoxin2 regulates trophoblast proliferation and migration through SPIB-HDAC2 pathway.1
374526342023SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway.0
357707292022SPI1-related protein inhibits cervical cancer cell progression and prevents macrophage cell migration.1
358314112022Integrated transcriptomic and regulatory network analyses uncovers the role of let-7b-5p, SPIB, and HLA-DPB1 in sepsis.3
359691722022Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB.3
357707292022SPI1-related protein inhibits cervical cancer cell progression and prevents macrophage cell migration.1
358314112022Integrated transcriptomic and regulatory network analyses uncovers the role of let-7b-5p, SPIB, and HLA-DPB1 in sepsis.3
359691722022Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB.3
345300562021SPIB acts as a tumor suppressor by activating the NFkB and JNK signaling pathways through MAP4K1 in colorectal cancer cells.9
345300562021SPIB acts as a tumor suppressor by activating the NFkB and JNK signaling pathways through MAP4K1 in colorectal cancer cells.9
321299362020SPIB promotes anoikis resistance via elevated autolysosomal process in lung cancer cells.12

Citation

Dessen P

SPIB (Spi-B transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42374/cancer-prone-explorer/css/gene-explorer/