SPIB (Spi-B transcription factor)

SPIB (Spi-B transcription factor)

2003-02-01 Affiliation

Identity

HGNC

LOCATION

19q13.33

LOCUSID

ALIAS

SPI-B

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6689
MIM: 606802
HGNC: 11242
Ensembl: ENSG00000269404

Variants:

dbSNP: 6689
ClinVar: 6689
TCGA: ENSG00000269404
COSMIC: SPIB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000269404	ENST00000270632	Q01892
ENSG00000269404	ENST00000439922	Q01892
ENSG00000269404	ENST00000594685	M0R2J9
ENSG00000269404	ENST00000595883	Q01892
ENSG00000269404	ENST00000595883	A0A024R4I5
ENSG00000269404	ENST00000596074	M0R037
ENSG00000269404	ENST00000597855	M0QXA8

Expression (GTEx)

0

10

20

30

40

50

60

70

80

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38622980	2024	IGSF10 inhibits the metastasis of lung adenocarcinoma via the Spi-B/Integrin-β1 signaling pathway.	0
38622980	2024	IGSF10 inhibits the metastasis of lung adenocarcinoma via the Spi-B/Integrin-β1 signaling pathway.	0
36400181	2023	Peroxiredoxin2 regulates trophoblast proliferation and migration through SPIB-HDAC2 pathway.	1
37452634	2023	SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway.	0
36400181	2023	Peroxiredoxin2 regulates trophoblast proliferation and migration through SPIB-HDAC2 pathway.	1
37452634	2023	SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway.	0
35770729	2022	SPI1-related protein inhibits cervical cancer cell progression and prevents macrophage cell migration.	1
35831411	2022	Integrated transcriptomic and regulatory network analyses uncovers the role of let-7b-5p, SPIB, and HLA-DPB1 in sepsis.	3
35969172	2022	Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB.	3
35770729	2022	SPI1-related protein inhibits cervical cancer cell progression and prevents macrophage cell migration.	1
35831411	2022	Integrated transcriptomic and regulatory network analyses uncovers the role of let-7b-5p, SPIB, and HLA-DPB1 in sepsis.	3
35969172	2022	Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB.	3
34530056	2021	SPIB acts as a tumor suppressor by activating the NFkB and JNK signaling pathways through MAP4K1 in colorectal cancer cells.	9
34530056	2021	SPIB acts as a tumor suppressor by activating the NFkB and JNK signaling pathways through MAP4K1 in colorectal cancer cells.	9
32129936	2020	SPIB promotes anoikis resistance via elevated autolysosomal process in lung cancer cells.	12

Citation

Dessen P

SPIB (Spi-B transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42374/gene-fusions/css/lib/js/lib/bootstrap.min.js