TBK1 (TANK binding kinase 1)

2003-06-01  

Identity

HGNC
TBK1
LOCATION
12q14.2
LOCUSID
29110
ALIAS
FTDALS4,IIAE8,NAK,T2K
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29110
MIM: 604834
HGNC: 11584
Ensembl: ENSG00000183735

Variants:

dbSNP: 29110
ClinVar: 29110
TCGA: ENSG00000183735
COSMIC: TBK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183735ENST00000331710Q9UHD2
ENSG00000183735ENST00000538890F5H1A3
ENSG00000183735ENST00000539810F5GZI4
ENSG00000183735ENST00000540417F5H206
ENSG00000183735ENST00000650708A0A494C0R4
ENSG00000183735ENST00000650762A0A494C0X2
ENSG00000183735ENST00000650786A0A494BZY3
ENSG00000183735ENST00000650790Q9UHD2
ENSG00000183735ENST00000650997A0A494C045
ENSG00000183735ENST00000651014A0A494C167
ENSG00000183735ENST00000651262A0A494C0A8
ENSG00000183735ENST00000651878A0A494C1I2
ENSG00000183735ENST00000652389A0A494C079
ENSG00000183735ENST00000652537A0A494C1M6
ENSG00000183735ENST00000652657A0A494C148

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Hepatitis BKEGGhsa05161
Ras signaling pathwayKEGGhsa04014
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonREACTOMER-HSA-936964
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF3-dependent IRF activation pathwayREACTOMER-HSA-918233
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
ZBP1(DAI) mediated induction of type I IFNsREACTOMER-HSA-1606322
IRF3 mediated activation of type 1 IFNREACTOMER-HSA-1606341
STING mediated induction of host immune responsesREACTOMER-HSA-1834941
IRF3-mediated induction of type I IFNREACTOMER-HSA-3270619
STAT6-mediated induction of chemokinesREACTOMER-HSA-3249367
Regulation of innate immune responses to cytosolic DNAREACTOMER-HSA-3134975
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377339212024AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer.0
380075522024Activating STING/TBK1 suppresses tumor growth via degrading HPV16/18 E7 oncoproteins in cervical cancer.3
380383902024Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1.2
380599002024NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.0
381860002024STING upregulation mediates ferroptosis and inflammatory response in lupus nephritis by upregulating TBK1 and activating NF-κB signal pathway.0
382115882024Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.0
382871892024Optineurin provides a mitophagy contact site for TBK1 activation.3
383516592024Phosphorylation of AGO2 by TBK1 Promotes the Formation of Oncogenic miRISC in NSCLC.2
385173322024A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.0
385637322024The Ca(2+)-dependent phosphatase calcineurin dephosphorylates TBK1 to suppress antiviral innate immunity.0
386737282024TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22.0
388147802024TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery.1
388584972024Suppression of smooth muscle cell inflammation by myocardin-related transcription factors involves inactivation of TANK-binding kinase 1.1
388722302024Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations.0
389321692024cGAS-STING-TBK1 Signaling Promotes Valproic Acid-Responsive Human Cytomegalovirus Immediate-Early Transcription during Infection of Incompletely Differentiated Myeloid Cells.0

Citation

Dessen P

TBK1 (TANK binding kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42480