TCF7 (transcription factor 7)

2003-02-01 Affiliation

Identity

HGNC

TCF7

LOCATION

5q31.1

LOCUSID

6932

ALIAS

TCF-1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6932
MIM: 189908
HGNC: 11639
Ensembl: ENSG00000081059

Variants:

dbSNP: 6932
ClinVar: 6932
TCGA: ENSG00000081059
COSMIC: TCF7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000081059	ENST00000342854	P36402
ENSG00000081059	ENST00000378560	P36402
ENSG00000081059	ENST00000395023	P36402
ENSG00000081059	ENST00000395029	B7WNT5
ENSG00000081059	ENST00000517741	E5RGJ5
ENSG00000081059	ENST00000517799	H0YAR8
ENSG00000081059	ENST00000517851	E5RGQ1
ENSG00000081059	ENST00000517855	H0YBC8
ENSG00000081059	ENST00000518887	E5RJ51
ENSG00000081059	ENST00000518915	P36402
ENSG00000081059	ENST00000519037	E5RHL1
ENSG00000081059	ENST00000519447	E5RGJ5
ENSG00000081059	ENST00000520652	H0YBM1
ENSG00000081059	ENST00000520699	H0YBP2
ENSG00000081059	ENST00000520958	P36402
ENSG00000081059	ENST00000521639	E5RG75
ENSG00000081059	ENST00000522375	E5RG34

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Wnt signaling pathway	KEGG	ko04310
Adherens junction	KEGG	ko04520
Melanogenesis	KEGG	ko04916
Colorectal cancer	KEGG	ko05210
Endometrial cancer	KEGG	ko05213
Prostate cancer	KEGG	ko05215
Thyroid cancer	KEGG	ko05216
Basal cell carcinoma	KEGG	ko05217
Acute myeloid leukemia	KEGG	ko05221
Wnt signaling pathway	KEGG	hsa04310
Adherens junction	KEGG	hsa04520
Melanogenesis	KEGG	hsa04916
Pathways in cancer	KEGG	hsa05200
Colorectal cancer	KEGG	hsa05210
Endometrial cancer	KEGG	hsa05213
Prostate cancer	KEGG	hsa05215
Thyroid cancer	KEGG	hsa05216
Basal cell carcinoma	KEGG	hsa05217
Acute myeloid leukemia	KEGG	hsa05221
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG	ko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG	hsa05412
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Wnt signaling	KEGG	hsa_M00677
Wnt signaling	KEGG	M00677
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Wnt	REACTOME	R-HSA-195721
Degradation of beta-catenin by the destruction complex	REACTOME	R-HSA-195253
Repression of WNT target genes	REACTOME	R-HSA-4641265
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Formation of the beta-catenin:TCF transactivating complex	REACTOME	R-HSA-201722
Binding of TCF/LEF:CTNNB1 to target gene promoters	REACTOME	R-HSA-4411364
Deactivation of the beta-catenin transactivating complex	REACTOME	R-HSA-3769402
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
Ca2+ pathway	REACTOME	R-HSA-4086398
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38169425	2024	Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function.	0
38169425	2024	Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function.	0
36565920	2023	Pancreatic stellate cells exploit Wnt/β-catenin/TCF7-mediated glutamine metabolism to promote pancreatic cancer cells growth.	10
36583231	2023	LncRNA TCF7 contributes to high glucose-induced damage in human podocytes by up-regulating SEMA3A via sponging miR-16-5p.	3
36802434	2023	Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1.	2
36988257	2023	Inhibition of ox-LDL-induced endothelial cell injury by LINC02381 knockdown through the microRNA-491-5p/transcription factor 7 axis.	0
37536668	2023	Characterization of TCF-1 and its relationship between CD8+ TIL densities and immune checkpoints and their joint influences on prognoses of lung adenocarcinoma patients.	2
37801516	2023	TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma.	0
36565920	2023	Pancreatic stellate cells exploit Wnt/β-catenin/TCF7-mediated glutamine metabolism to promote pancreatic cancer cells growth.	10
36583231	2023	LncRNA TCF7 contributes to high glucose-induced damage in human podocytes by up-regulating SEMA3A via sponging miR-16-5p.	3
36802434	2023	Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1.	2
36988257	2023	Inhibition of ox-LDL-induced endothelial cell injury by LINC02381 knockdown through the microRNA-491-5p/transcription factor 7 axis.	0
37536668	2023	Characterization of TCF-1 and its relationship between CD8+ TIL densities and immune checkpoints and their joint influences on prognoses of lung adenocarcinoma patients.	2
37801516	2023	TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma.	0
35460379	2022	Tcf-1 protects anti-tumor TCR-engineered CD8(+) T-cells from GzmB mediated self-destruction.	1

Citation

Dessen P

TCF7 (transcription factor 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42494