SERINC3 (serine incorporator 3)

2003-02-01  

Identity

HGNC
SERINC3
LOCATION
20q13.12
LOCUSID
10955
ALIAS
AIGP1,DIFF33,SBBI99,TDE,TDE1,TMS-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10955
MIM: 607165
HGNC: 11699
Ensembl: ENSG00000132824

Variants:

dbSNP: 10955
ClinVar: 10955
TCGA: ENSG00000132824
COSMIC: SERINC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132824ENST00000255175Q13530
ENSG00000132824ENST00000342374Q13530
ENSG00000132824ENST00000411544Q5H936

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614
Serine biosynthesisREACTOMER-HSA-977347

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
327882122020HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo-electron and TIRF microscopy.27
327882122020HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo-electron and TIRF microscopy.27
311863272019Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5.18
311863272019Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5.18
264167332015SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef.271
264167332015SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef.271
165474972006Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis.16
165474972006Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis.16

Citation

Dessen P

SERINC3 (serine incorporator 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42502/js/lib/favicon/deep-insight-explorer/meetings/