SERINC2 (serine incorporator 2)

2003-11-01  

Identity

HGNC
SERINC2
LOCATION
1p35.2
LOCUSID
347735
ALIAS
FKSG84,PRO0899,TDE2,TDE2L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 347735
MIM: 614549
HGNC: 23231
Ensembl: ENSG00000168528

Variants:

dbSNP: 347735
ClinVar: 347735
TCGA: ENSG00000168528
COSMIC: SERINC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168528ENST00000373709Q96SA4
ENSG00000168528ENST00000373710Q96SA4
ENSG00000168528ENST00000536384Q96SA4
ENSG00000168528ENST00000536859Q96SA4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614
Serine biosynthesisREACTOMER-HSA-977347

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
342882432021SERINC2 increases the risk of bipolar disorder in the Chinese population.0
342882432021SERINC2 increases the risk of bipolar disorder in the Chinese population.0
292680822018Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.32
292680822018Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.32
289359722017Chromosomal microarray analysis in a cohort of underrepresented population identifies SERINC2 as a novel candidate gene for autism spectrum disorder.15
289359722017Chromosomal microarray analysis in a cohort of underrepresented population identifies SERINC2 as a novel candidate gene for autism spectrum disorder.15
244245052014siRNA-mediated knockdown of hTDE2 retards cell cycle progression through transcriptional activation of p21.3
244245052014siRNA-mediated knockdown of hTDE2 retards cell cycle progression through transcriptional activation of p21.3
234554912013NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.19
237783222013Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent.11
234554912013NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.19
237783222013Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent.11
217528292011Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.522
217528292011Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.522

Citation

Dessen P

SERINC2 (serine incorporator 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42504