TNS3 (tensin 3)

2003-06-01  

Identity

HGNC
TNS3
LOCATION
7p12.3
LOCUSID
64759
ALIAS
TEM6,TENS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64759
MIM: 606825
HGNC: 21616
Ensembl: ENSG00000136205

Variants:

dbSNP: 64759
ClinVar: 64759
TCGA: ENSG00000136205
COSMIC: TNS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136205ENST00000311160Q68CZ2
ENSG00000136205ENST00000413551C9JWN9
ENSG00000136205ENST00000415929C9JTD0
ENSG00000136205ENST00000428457H7BZ64
ENSG00000136205ENST00000434451C9JUW5
ENSG00000136205ENST00000442536Q68CZ2
ENSG00000136205ENST00000450444C9JHU5
ENSG00000136205ENST00000457718E9PCX8
ENSG00000136205ENST00000458317Q68CZ2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET interacts with TNS proteinsREACTOMER-HSA-8875513

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376686822023Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cells.2
381095442023Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination.1
376686822023Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cells.2
381095442023Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination.1
356870212022PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.5
359541772022Tensin Regulates Fundamental Biological Processes by Interacting with Integrins of Tonsil-Derived Mesenchymal Stem Cells.2
359876232022Abnormal TNS3 gene methylation in patients with congenital scoliosis.1
356870212022PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.5
359541772022Tensin Regulates Fundamental Biological Processes by Interacting with Integrins of Tonsil-Derived Mesenchymal Stem Cells.2
359876232022Abnormal TNS3 gene methylation in patients with congenital scoliosis.1
338243092021MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity.6
338243092021MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity.6
319058412019Tensin-3 Regulates Integrin-Mediated Proliferation and Differentiation of Tonsil-Derived Mesenchymal Stem Cells.10
319058412019Tensin-3 Regulates Integrin-Mediated Proliferation and Differentiation of Tonsil-Derived Mesenchymal Stem Cells.10
285152312017A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity.10

Citation

Dessen P

TNS3 (tensin 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42518/haematological-explorer/case-report-explorer/teaching-explorer/