TGIF2 (TGFB induced factor homeobox 2)

TGIF2 (TGFB induced factor homeobox 2)

2003-12-01 Affiliation

Identity

HGNC

LOCATION

20q11.23

LOCUSID

ALIAS

-

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 60436
MIM: 607294
HGNC: 15764
Ensembl: ENSG00000118707

Variants:

dbSNP: 60436
ClinVar: 60436
TCGA: ENSG00000118707
COSMIC: TGIF2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000118707	ENST00000373872	Q9GZN2
ENSG00000118707	ENST00000373874	Q9GZN2
ENSG00000118707	ENST00000557885	U3KQS0
ENSG00000118707	ENST00000558028	H0YKN5
ENSG00000118707	ENST00000558465	U3KQ25
ENSG00000118707	ENST00000560025	Q9GZN2
ENSG00000118707	ENST00000561398	U3KQB5
ENSG00000118707	ENST00000611732	Q9GZN2
ENSG00000118707	ENST00000650844	Q9GZN2

Expression (GTEx)

0

10

20

30

40

50

60

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
TGF-beta signaling pathway	KEGG	ko04350
TGF-beta signaling pathway	KEGG	hsa04350
Signal Transduction	REACTOME	R-HSA-162582
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	REACTOME	R-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	REACTOME	R-HSA-2173796
Downregulation of SMAD2/3:SMAD4 transcriptional activity	REACTOME	R-HSA-2173795
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436

References

Pubmed ID	Year	Title	Citations
36647029	2023	Phosphorylation of TGIF2 represents a therapeutic target that drives EMT and metastasis of lung adenocarcinoma.	5
36647029	2023	Phosphorylation of TGIF2 represents a therapeutic target that drives EMT and metastasis of lung adenocarcinoma.	5
34471941	2022	Circular RNA circMMP1 Contributes to the Progression of Glioma Through Regulating TGIF2 Expression by Sponging miR-195-5p.	3
34471941	2022	Circular RNA circMMP1 Contributes to the Progression of Glioma Through Regulating TGIF2 Expression by Sponging miR-195-5p.	3
33714261	2021	Circ-RNF13, as an oncogene, regulates malignant progression of HBV-associated hepatocellular carcinoma cells and HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2.	13
34741437	2021	Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer.	7
33714261	2021	Circ-RNF13, as an oncogene, regulates malignant progression of HBV-associated hepatocellular carcinoma cells and HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2.	13
34741437	2021	Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer.	7
32572908	2020	TGIF2 promotes cervical cancer metastasis by negatively regulating FCMR.	6
32709240	2020	miR-541 serves as a prognostic biomarker of osteosarcoma and its regulatory effect on tumor cell proliferation, migration and invasion by targeting TGIF2.	6
32572908	2020	TGIF2 promotes cervical cancer metastasis by negatively regulating FCMR.	6
32709240	2020	miR-541 serves as a prognostic biomarker of osteosarcoma and its regulatory effect on tumor cell proliferation, migration and invasion by targeting TGIF2.	6
30632703	2019	Three inflammation-related genes could predict risk in prognosis and metastasis of patients with breast cancer.	9
30825648	2019	Effects on hepatic lipid metabolism in human hepatoma cells following overexpression of TGFβ induced factor homeobox 1 or 2.	1
31113203	2019	The function of microRNA-34a in osteoarthritis.	7

Citation

Dessen P

TGIF2 (TGFB induced factor homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42544/cancer-prone-explorer/css/js/_common.js