THPO (thrombopoietin)

2003-02-01  

Identity

HGNC
THPO
LOCATION
3q27.1
LOCUSID
7066
ALIAS
MGDF,MKCSF,ML,MPLLG,THCYT1,TPO
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7066
MIM: 600044
HGNC: 11795
Ensembl: ENSG00000090534

Variants:

dbSNP: 7066
ClinVar: 7066
TCGA: ENSG00000090534
COSMIC: THPO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090534ENST00000421442F8W6L1
ENSG00000090534ENST00000445696P40225
ENSG00000090534ENST00000477594A0A2R8Y734
ENSG00000090534ENST00000645603A0A3B3ITS0
ENSG00000090534ENST00000647395P40225
ENSG00000090534ENST00000649095A0A3B3ITS0
ENSG00000090534ENST00000650229Q5FBX8

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Hematopoietic cell lineageKEGGko04640
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Hematopoietic cell lineageKEGGhsa04640
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Platelet Aggregation (Plug Formation)REACTOMER-HSA-76009

References

Pubmed IDYearTitleCitations
379626212024Hereditary thrombocythemia due to splicing donor site mutation of THPO in a Japanese family.0
379626212024Hereditary thrombocythemia due to splicing donor site mutation of THPO in a Japanese family.0
362264972023Defective binding of ETS1 and STAT4 due to a mutation in the promoter region of THPO as a novel mechanism of congenital amegakaryocytic thrombocytopenia.1
362264972023Defective binding of ETS1 and STAT4 due to a mutation in the promoter region of THPO as a novel mechanism of congenital amegakaryocytic thrombocytopenia.1
365346592022Novel THPO variant in hereditary thrombocytopenia: A potential candidate variant for predisposition to myeloid neoplasm.0
365346592022Novel THPO variant in hereditary thrombocytopenia: A potential candidate variant for predisposition to myeloid neoplasm.0
332380002021Increased B4GALT1 expression is associated with platelet surface galactosylation and thrombopoietin plasma levels in MPNs.8
336730412021Cooperative Role of Thrombopoietin and Vascular Endothelial Growth Factor-A in the Progression of Liver Cirrhosis to Hepatocellular Carcinoma.5
342470392021Clinical applications of thrombopoietin silencing: A possible therapeutic role in COVID-19?1
332380002021Increased B4GALT1 expression is associated with platelet surface galactosylation and thrombopoietin plasma levels in MPNs.8
336730412021Cooperative Role of Thrombopoietin and Vascular Endothelial Growth Factor-A in the Progression of Liver Cirrhosis to Hepatocellular Carcinoma.5
342470392021Clinical applications of thrombopoietin silencing: A possible therapeutic role in COVID-19?1
321506072020Monoallelic loss-of-function THPO variants cause heritable thrombocytopenia.7
323378442020Endogenous thrombopoietin promotes non-small-cell lung carcinoma cell proliferation and migration by regulating EGFR signalling.4
323412062020c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis.4

Citation

Dessen P

THPO (thrombopoietin)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42552/deep-insight-explorer/