TIAM2 (TIAM Rac1 associated GEF 2)

2003-06-01  

Identity

HGNC
TIAM2
LOCATION
6q25.2
LOCUSID
26230
ALIAS
STEF,TIAM-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26230
MIM: 604709
HGNC: 11806
Ensembl: ENSG00000146426

Variants:

dbSNP: 26230
ClinVar: 26230
TCGA: ENSG00000146426
COSMIC: TIAM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146426ENST00000275246Q8IVF5
ENSG00000146426ENST00000360366Q8IVF5
ENSG00000146426ENST00000456877Q8IVF5
ENSG00000146426ENST00000461783Q8IVF5
ENSG00000146426ENST00000462408H7C5V6
ENSG00000146426ENST00000528391E9PKT1
ENSG00000146426ENST00000528535E9PMZ8
ENSG00000146426ENST00000529824Q8IVF5
ENSG00000146426ENST00000535231F5H1M3
ENSG00000146426ENST00000535583F5H6W6
ENSG00000146426ENST00000538270F5H6R0
ENSG00000146426ENST00000543712H0YGV1
ENSG00000146426ENST00000545347F5H1M3

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383476322024Novel genetic markers for chronic kidney disease in a geographically isolated population of Indigenous Australians: Individual and multiple phenotype genome-wide association study.0
383476322024Novel genetic markers for chronic kidney disease in a geographically isolated population of Indigenous Australians: Individual and multiple phenotype genome-wide association study.0
378010652023TIAM2S-positive microglia enhance inflammation and neurotoxicity through soluble ICAM-1-mediated immune priming.1
378010652023TIAM2S-positive microglia enhance inflammation and neurotoxicity through soluble ICAM-1-mediated immune priming.1
332846592021Elevated TIAM2 expression promotes tumor progression and is associated with unfavorable prognosis in pancreatic cancer.2
347316232021FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma.16
332846592021Elevated TIAM2 expression promotes tumor progression and is associated with unfavorable prognosis in pancreatic cancer.2
347316232021FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma.16
298443642018STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.25
298443642018STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.25
267634862016Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma.15
275977582016Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion.23
267634862016Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma.15
275977582016Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion.23
243775222013TIAM2 enhances non-small cell lung cancer cell invasion and motility.13

Citation

Dessen P

TIAM2 (TIAM Rac1 associated GEF 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42558/case-report-explorer/js/js/web-card-_common.js