TIMM23 (translocase of inner mitochondrial membrane 23)

2003-06-01 Affiliation

Identity

HGNC

TIMM23

LOCATION

10q11.22

LOCUSID

100287932

ALIAS

TIM23

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 100287932
MIM: 605034
HGNC: 17312
Ensembl: ENSG00000265354

Variants:

dbSNP: 100287932
ClinVar: 100287932
TCGA: ENSG00000265354
COSMIC: TIMM23

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000265354	ENST00000580018	O14925

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Mitochondrial protein import	REACTOME	R-HSA-1268020

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37044213	2023	NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming.	0
37044213	2023	NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming.	0
32074073	2020	From TOM to the TIM23 complex - handing over of a precursor.	22
33197464	2020	Mitochondrial Oxidative Stress Induces Rapid Intermembrane Space/Matrix Translocation of Apurinic/Apyrimidinic Endonuclease 1 Protein through TIM23 Complex.	6
32074073	2020	From TOM to the TIM23 complex - handing over of a precursor.	22
33197464	2020	Mitochondrial Oxidative Stress Induces Rapid Intermembrane Space/Matrix Translocation of Apurinic/Apyrimidinic Endonuclease 1 Protein through TIM23 Complex.	6
31346086	2019	Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23.	37
31346086	2019	Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23.	37
29413900	2018	Expression of the human TIMM23 and TIMM23B genes is regulated by the GABP transcription factor.	3
29413900	2018	Expression of the human TIMM23 and TIMM23B genes is regulated by the GABP transcription factor.	3
27178215	2016	Interaction of divalent metal ions with human translocase of inner membrane of mitochondria Tim23.	0
27178215	2016	Interaction of divalent metal ions with human translocase of inner membrane of mitochondria Tim23.	0
24636990	2014	Unraveling the intricate organization of mammalian mitochondrial presequence translocases: existence of multiple translocases for maintenance of mitochondrial function.	24
25519239	2014	Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.	15
24636990	2014	Unraveling the intricate organization of mammalian mitochondrial presequence translocases: existence of multiple translocases for maintenance of mitochondrial function.	24

Citation

Dessen P

TIMM23 (translocase of inner mitochondrial membrane 23)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42566