SEC62 (SEC62 homolog, preprotein translocation factor)

2003-06-01  

Identity

HGNC
LOCATION
3q26.2
LOCUSID
ALIAS
Dtrp1,HTP1,TLOC1,TP-1
FUSION GENES

Other Information

Locus ID:

NCBI: 7095
MIM: 602173
HGNC: 11846
Ensembl: ENSG00000008952

Variants:

dbSNP: 7095
ClinVar: 7095
TCGA: ENSG00000008952
COSMIC: SEC62

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008952ENST00000337002Q99442
ENSG00000008952ENST00000460513F8WF48
ENSG00000008952ENST00000469515F8WCJ7
ENSG00000008952ENST00000480708Q99442
ENSG00000008952ENST00000487736F8WDG8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Protein exportKEGGhsa03060
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367151822023Splicing factor SNRPA associated with microvascular invasion promotes hepatocellular carcinoma metastasis through activating NOTCH1/Snail pathway and is mediated by circSEC62/miR-625-5p axis.6
372985282023The 3q Oncogene SEC62 Predicts Response to Neoadjuvant Chemotherapy and Regulates Tumor Cell Migration in Triple Negative Breast Cancer.1
367151822023Splicing factor SNRPA associated with microvascular invasion promotes hepatocellular carcinoma metastasis through activating NOTCH1/Snail pathway and is mediated by circSEC62/miR-625-5p axis.6
372985282023The 3q Oncogene SEC62 Predicts Response to Neoadjuvant Chemotherapy and Regulates Tumor Cell Migration in Triple Negative Breast Cancer.1
351657632022Sec62 promotes gastric cancer metastasis through mediating UPR-induced autophagy activation.13
351657632022Sec62 promotes gastric cancer metastasis through mediating UPR-induced autophagy activation.13
338584762021Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway.66
338584762021Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway.66
321337892020Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import.22
321337892020Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import.22
307473292019Identification of 3q oncogene SEC62 as a marker for distant metastasis and poor clinical outcome in invasive ductal breast cancer.14
313953422019MiR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m(6)A-caused stabilization of SEC62.77
307473292019Identification of 3q oncogene SEC62 as a marker for distant metastasis and poor clinical outcome in invasive ductal breast cancer.14
313953422019MiR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m(6)A-caused stabilization of SEC62.77
280028012017Effect of 3q oncogenes SEC62 and SOX2 on lymphatic metastasis and clinical outcome of head and neck squamous cell carcinomas.21

Citation

Dessen P

SEC62 (SEC62 homolog, preprotein translocation factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42579/sec62