TNFRSF14 (TNF receptor superfamily member 14)

2003-06-01  

Identity

HGNC
TNFRSF14
LOCATION
1p36.32
LOCUSID
8764
ALIAS
ATAR,CD270,HVEA,HVEM,LIGHTR,TR2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8764
MIM: 602746
HGNC: 11912
Ensembl: ENSG00000157873

Variants:

dbSNP: 8764
ClinVar: 8764
TCGA: ENSG00000157873
COSMIC: TNFRSF14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157873ENST00000355716Q92956
ENSG00000157873ENST00000355716A0A024R052
ENSG00000157873ENST00000409119B9A034
ENSG00000157873ENST00000426449F6UPZ7
ENSG00000157873ENST00000434817F6Q0M4
ENSG00000157873ENST00000435221F6Q0M4
ENSG00000157873ENST00000451778F6Q0M4
ENSG00000157873ENST00000482602A0A0D9SF52

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Costimulation by the CD28 familyREACTOMER-HSA-388841
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377229592024Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis.0
377229592024Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis.0
370339272023Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1(-) stem cell-like T cells over PD-1(+) T cells curbing tumor progression.1
373312972023MIF promotes Th17 cell differentiation in Hashimoto's thyroiditis by binding HVEM and activating NF-κB signaling pathway.1
370339272023Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1(-) stem cell-like T cells over PD-1(+) T cells curbing tumor progression.1
373312972023MIF promotes Th17 cell differentiation in Hashimoto's thyroiditis by binding HVEM and activating NF-κB signaling pathway.1
351961502022Clinical Significance of BTLA and HVEM Expression on Circulating CD4(+) T and CD8(+) T Cells in Chronic Hepatitis B Virus Infection.4
355373222022The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases.10
360815082022BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM.10
365527852022Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2.6
351961502022Clinical Significance of BTLA and HVEM Expression on Circulating CD4(+) T and CD8(+) T Cells in Chronic Hepatitis B Virus Infection.4
355373222022The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases.10
360815082022BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM.10
365527852022Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2.6
344785262021Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype.12

Citation

Dessen P

TNFRSF14 (TNF receptor superfamily member 14)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42615/css/lib/favicon/favicon-16x16.png