TNFRSF18 (TNF receptor superfamily member 18)

2003-05-01  

Identity

HGNC
TNFRSF18
LOCATION
1p36.33
LOCUSID
8784
ALIAS
AITR,CD357,ENERGEN,GITR,GITR-D

Other Information

Locus ID:

NCBI: 8784
MIM: 603905
HGNC: 11914
Ensembl: ENSG00000186891

Variants:

dbSNP: 8784
ClinVar: 8784
TCGA: ENSG00000186891
COSMIC: TNFRSF18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186891ENST00000328596Q9Y5U5
ENSG00000186891ENST00000379265Q9Y5U5
ENSG00000186891ENST00000379268Q9Y5U5
ENSG00000186891ENST00000486728J3KT02

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361552592023GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells.5
361552592023GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells.5
331226022022Phenotypic Changes of PD-1 and GITR in T Cells Are Associated With Hepatitis B Surface Antigen Seroclearance.4
349080082022DNA Methylation and mRNA Expression of OX40 (TNFRSF4) and GITR (TNFRSF18, AITR) in Head and Neck Squamous Cell Carcinoma Correlates With HPV Status, Mutational Load, an Interferon-γ Signature, Signatures of Immune Infiltrates, and Survival.6
331226022022Phenotypic Changes of PD-1 and GITR in T Cells Are Associated With Hepatitis B Surface Antigen Seroclearance.4
349080082022DNA Methylation and mRNA Expression of OX40 (TNFRSF4) and GITR (TNFRSF18, AITR) in Head and Neck Squamous Cell Carcinoma Correlates With HPV Status, Mutational Load, an Interferon-γ Signature, Signatures of Immune Infiltrates, and Survival.6
332800892021Experimental Medicine Study to Measure Immune Checkpoint Receptors PD-1 and GITR Turnover Rates In Vivo in Humans.1
336540812021Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.10
341023052021Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis.3
345890882021GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori-Positive Gastritis.5
332800892021Experimental Medicine Study to Measure Immune Checkpoint Receptors PD-1 and GITR Turnover Rates In Vivo in Humans.1
336540812021Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.10
341023052021Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis.3
345890882021GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori-Positive Gastritis.5
322595292020GITR shapes humoral immunity by controlling the balance between follicular T helper cells and regulatory T follicular cells.7

Citation

Dessen P

TNFRSF18 (TNF receptor superfamily member 18)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42617/css/lib/css/css/lib/bootstrap.min.css