TNFRSF18 (TNF receptor superfamily member 18)

2003-05-01  

Identity

HGNC
LOCATION
1p36.33
LOCUSID
ALIAS
AITR,CD357,ENERGEN,GITR,GITR-D

Other Information

Locus ID:

NCBI: 8784
MIM: 603905
HGNC: 11914
Ensembl: ENSG00000186891

Variants:

dbSNP: 8784
ClinVar: 8784
TCGA: ENSG00000186891
COSMIC: TNFRSF18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186891ENST00000328596Q9Y5U5
ENSG00000186891ENST00000379265Q9Y5U5
ENSG00000186891ENST00000379268Q9Y5U5
ENSG00000186891ENST00000486728J3KT02

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
361552592023GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells.5
361552592023GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells.5
331226022022Phenotypic Changes of PD-1 and GITR in T Cells Are Associated With Hepatitis B Surface Antigen Seroclearance.4
349080082022DNA Methylation and mRNA Expression of OX40 (TNFRSF4) and GITR (TNFRSF18, AITR) in Head and Neck Squamous Cell Carcinoma Correlates With HPV Status, Mutational Load, an Interferon-γ Signature, Signatures of Immune Infiltrates, and Survival.6
331226022022Phenotypic Changes of PD-1 and GITR in T Cells Are Associated With Hepatitis B Surface Antigen Seroclearance.4
349080082022DNA Methylation and mRNA Expression of OX40 (TNFRSF4) and GITR (TNFRSF18, AITR) in Head and Neck Squamous Cell Carcinoma Correlates With HPV Status, Mutational Load, an Interferon-γ Signature, Signatures of Immune Infiltrates, and Survival.6
332800892021Experimental Medicine Study to Measure Immune Checkpoint Receptors PD-1 and GITR Turnover Rates In Vivo in Humans.1
336540812021Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.10
341023052021Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis.3
345890882021GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori-Positive Gastritis.5
332800892021Experimental Medicine Study to Measure Immune Checkpoint Receptors PD-1 and GITR Turnover Rates In Vivo in Humans.1
336540812021Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.10
341023052021Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis.3
345890882021GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori-Positive Gastritis.5
322595292020GITR shapes humoral immunity by controlling the balance between follicular T helper cells and regulatory T follicular cells.7

Citation

Dessen P

TNFRSF18 (TNF receptor superfamily member 18)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42617/deep-insight-explorer/img/favicon/manifest.json