TNFRSF1A (TNF receptor superfamily member 1A)

2003-02-01 Affiliation

Identity

HGNC

TNFRSF1A

LOCATION

12p13.31

LOCUSID

7132

ALIAS

CD120a,FPF,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR1,TNFR55,TNFR60,p55,p55-R,p60

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7132
MIM: 191190
HGNC: 11916
Ensembl: ENSG00000067182

Variants:

dbSNP: 7132
ClinVar: 7132
TCGA: ENSG00000067182
COSMIC: TNFRSF1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000067182	ENST00000162749	P19438
ENSG00000067182	ENST00000366159	P19438
ENSG00000067182	ENST00000440083	F5H6V7
ENSG00000067182	ENST00000534885	F5GWJ4
ENSG00000067182	ENST00000536194	F5H6Z2
ENSG00000067182	ENST00000539372	F5H8A6
ENSG00000067182	ENST00000540022	F5H061
ENSG00000067182	ENST00000543048	F5H4T5
ENSG00000067182	ENST00000543995	F5H7N1

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Cytokine-cytokine receptor interaction	KEGG	ko04060
mTOR signaling pathway	KEGG	ko04150
Apoptosis	KEGG	ko04210
Adipocytokine signaling pathway	KEGG	ko04920
Alzheimer's disease	KEGG	ko05010
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
MAPK signaling pathway	KEGG	hsa04010
Cytokine-cytokine receptor interaction	KEGG	hsa04060
mTOR signaling pathway	KEGG	hsa04150
Apoptosis	KEGG	hsa04210
Adipocytokine signaling pathway	KEGG	hsa04920
Alzheimer's disease	KEGG	hsa05010
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
NF-kappa B signaling pathway	KEGG	hsa04064
NF-kappa B signaling pathway	KEGG	ko04064
TNF signaling pathway	KEGG	hsa04668
TNF signaling pathway	KEGG	ko04668
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
TNFs bind their physiological receptors	REACTOME	R-HSA-5669034
Signal Transduction	REACTOME	R-HSA-162582
Death Receptor Signalling	REACTOME	R-HSA-73887
TNF signaling	REACTOME	R-HSA-75893
TNFR1-induced proapoptotic signaling	REACTOME	R-HSA-5357786
Insulin resistance	KEGG	hsa04931
TNFR1-induced NFkappaB signaling pathway	REACTOME	R-HSA-5357956
TNFR1-mediated ceramide production	REACTOME	R-HSA-5626978
Regulation of TNFR1 signaling	REACTOME	R-HSA-5357905
Apoptosis - multiple species	KEGG	ko04215
Apoptosis - multiple species	KEGG	hsa04215
Interleukin-10 signaling	REACTOME	R-HSA-6783783
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA10004	adalimumab	Chemical	ClinicalAnnotation	associated	PD	22480748
PA164713366	Tumor necrosis factor alpha (TNF-alpha) inhibitors	Chemical	ClinicalAnnotation	associated	PD	22480748, 24776844, 25311255
PA443434	Arthritis, Rheumatoid	Disease	ClinicalAnnotation	associated	PD	22480748, 25311255
PA443815	Crohn Disease	Disease	ClinicalAnnotation	associated	PD	24776844
PA446116	Inflammatory Bowel Diseases	Disease	ClinicalAnnotation	associated	PD	24776844
PA446198	Arthritis, Psoriatic	Disease	ClinicalAnnotation	associated	PD	22480748
PA449515	etanercept	Chemical	ClinicalAnnotation	associated	PD	22480748
PA452639	infliximab	Chemical	ClinicalAnnotation	associated	PD	22480748

References

Pubmed ID	Year	Title	Citations
38382266	2024	Progesterone modulates TNF receptors expression by Jurkat cells cultured with plasma from pregnant women with preeclampsia.	0
38562920	2024	Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement.	0
38865403	2024	Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients.	0
38382266	2024	Progesterone modulates TNF receptors expression by Jurkat cells cultured with plasma from pregnant women with preeclampsia.	0
38562920	2024	Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement.	0
38865403	2024	Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients.	0
36479675	2023	C-Reactive Protein, Interleukin-6, Trimethylamine-N-Oxide, Syndecan-1, Nitric Oxide, and Tumor Necrosis Factor Receptor-1 in Heart Failure with Preserved Versus Reduced Ejection Fraction: a Meta-Analysis.	2
36508390	2023	TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study.	1
36752501	2023	A novel TNFRSF1A mutation associated with TNF-receptor-associated periodic syndrome and its metabolic signature.	1
36830631	2023	Impact of Tumor Necrosis Factor Receptor 1 (TNFR1) Polymorphism on Dry Eye Disease.	0
37470237	2023	TNFRSF1A-pR92Q variant identifies a subset of patients more similar to systemic undifferentiated recurrent fever than TNF receptor-associated periodic syndrome.	0
38186567	2023	Identification of TNFRSF1A as a novel regulator of carfilzomib resistance in multiple myeloma.	0
36479675	2023	C-Reactive Protein, Interleukin-6, Trimethylamine-N-Oxide, Syndecan-1, Nitric Oxide, and Tumor Necrosis Factor Receptor-1 in Heart Failure with Preserved Versus Reduced Ejection Fraction: a Meta-Analysis.	2
36508390	2023	TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study.	1
36752501	2023	A novel TNFRSF1A mutation associated with TNF-receptor-associated periodic syndrome and its metabolic signature.	1

Citation

Dessen P

TNFRSF1A (TNF receptor superfamily member 1A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42620