TNFRSF1B (TNF receptor superfamily member 1B)

2003-02-01  

Identity

HGNC
TNFRSF1B
LOCATION
1p36.22
LOCUSID
7133
ALIAS
CD120b,TBPII,TNF-R-II,TNF-R75,TNFBR,TNFR1B,TNFR2,TNFR80,p75,p75TNFR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7133
MIM: 191191
HGNC: 11917
Ensembl: ENSG00000028137

Variants:

dbSNP: 7133
ClinVar: 7133
TCGA: ENSG00000028137
COSMIC: TNFRSF1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000028137ENST00000376259P20333
ENSG00000028137ENST00000536782B5A977

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Adipocytokine signaling pathwayKEGGko04920
Amyotrophic lateral sclerosis (ALS)KEGGko05014
Cytokine-cytokine receptor interactionKEGGhsa04060
Adipocytokine signaling pathwayKEGGhsa04920
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034
Neutrophil degranulationREACTOMER-HSA-6798695
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD18565259, 22129793, 25537528, 25850964
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD18565259, 22129793, 25537528, 25850964
PA445724Spondylitis, AnkylosingDiseaseClinicalAnnotationassociatedPD30075559
PA449515etanerceptChemicalClinicalAnnotationassociatedPD30075559
PA452639infliximabChemicalClinicalAnnotationassociatedPD18565259, 22129793, 25537528, 25850964

References

Pubmed IDYearTitleCitations
381429152024Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion.0
383412702024Tregs from human blood differentiate into nonlymphoid tissue-resident effector cells upon TNFR2 costimulation.0
383644582024Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients.0
383822662024Progesterone modulates TNF receptors expression by Jurkat cells cultured with plasma from pregnant women with preeclampsia.0
384741152024TNFRSF1B Gene Variants in Clinicopathological Aspects and Prognosis of Patients with Cutaneous Melanoma.0
385379322024Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation.0
388654032024Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients.0
381429152024Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion.0
383412702024Tregs from human blood differentiate into nonlymphoid tissue-resident effector cells upon TNFR2 costimulation.0
383644582024Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients.0
383822662024Progesterone modulates TNF receptors expression by Jurkat cells cultured with plasma from pregnant women with preeclampsia.0
384741152024TNFRSF1B Gene Variants in Clinicopathological Aspects and Prognosis of Patients with Cutaneous Melanoma.0
385379322024Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation.0
388654032024Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients.0
368655372023TNFR2 expression predicts the responses to immune checkpoint inhibitor treatments.2

Citation

Dessen P

TNFRSF1B (TNF receptor superfamily member 1B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42621/gene-fusions/deep-insight-explorer/tumors-explorer/