TNFRSF25 (TNF receptor superfamily member 25)

2003-05-01  

Identity

HGNC
TNFRSF25
LOCATION
1p36.31
LOCUSID
8718
ALIAS
APO-3,DDR3,DR3,GEF720,LARD,PLEKHG5,TNFRSF12,TR3,TRAMP,WSL-1,WSL-LR

Other Information

Locus ID:

NCBI: 8718
MIM: 603366
HGNC: 11910
Ensembl: ENSG00000215788

Variants:

dbSNP: 8718
ClinVar: 8718
TCGA: ENSG00000215788
COSMIC: TNFRSF25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000215788ENST00000348333Q93038
ENSG00000215788ENST00000351748Q93038
ENSG00000215788ENST00000351959Q93038
ENSG00000215788ENST00000356876Q93038
ENSG00000215788ENST00000377782Q93038
ENSG00000215788ENST00000414040Q93038
ENSG00000215788ENST00000480393A0A0C4DGF3
ENSG00000215788ENST00000481401K7EJY9
ENSG00000215788ENST00000485036Q93038
ENSG00000215788ENST00000502588Q93038
ENSG00000215788ENST00000502730Q93038
ENSG00000215788ENST00000510563Q93038
ENSG00000215788ENST00000647810A0A3B3ISD9

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

References

Pubmed IDYearTitleCitations
350634042022Co-Expression and Functional Interactions of Death Receptor 3 and E-Selectin in Clear Cell Renal Cell Carcinoma.2
350634042022Co-Expression and Functional Interactions of Death Receptor 3 and E-Selectin in Clear Cell Renal Cell Carcinoma.2
316087212021Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia.10
316087212021Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia.10
311358762020Pathologic up-regulation of TNFSF15-TNFRSF25 axis sustains endothelial dysfunction in unprovoked venous thromboembolism.7
323973432020The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens.6
331771612020TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses.1
311358762020Pathologic up-regulation of TNFSF15-TNFRSF25 axis sustains endothelial dysfunction in unprovoked venous thromboembolism.7
323973432020The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens.6
331771612020TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses.1
312999412019Oestrogen-deficiency induces bone loss by modulating CD14(+) monocyte and CD4(+) T cell DR3 expression and serum TL1A levels.5
313587602019Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation.26
316281532019The TL1A-DR3 Axis Selectively Drives Effector Functions in Human MAIT Cells.4
312999412019Oestrogen-deficiency induces bone loss by modulating CD14(+) monocyte and CD4(+) T cell DR3 expression and serum TL1A levels.5
313587602019Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation.26

Citation

Dessen P

TNFRSF25 (TNF receptor superfamily member 25)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42625/gene-explorer/favicon/js/lib/popper.js