Identity
HGNC
LOCATION
13q14.11
LOCUSID
ALIAS
CD254,ODF,OPGL,OPTB2,RANKL,TNLG6B,TRANCE,hRANKL2,sOdf
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8600
MIM: 602642
HGNC: 11926
Ensembl: ENSG00000120659
Variants:
dbSNP: 8600
ClinVar: 8600
TCGA: ENSG00000120659
COSMIC: TNFSF11
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PD | ||
| PA448432 | anastrozole | Chemical | ClinicalAnnotation | associated | PD | ||
| PA450196 | letrozole | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38382805 | 2024 | RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway. | 0 |
| 38583439 | 2024 | Osteoprotegerin and receptor activator of the nuclear factor kappa B ligand (RANKL) in healthy pubertal girls - relationships with physical growth and classical bone turnover markers. | 0 |
| 38594779 | 2024 | Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma. | 0 |
| 38614129 | 2024 | Accumulation of γδT cells in the decidua is promoted by RANKL which upregulates ICAM-1 via NF-κB. | 0 |
| 38382805 | 2024 | RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway. | 0 |
| 38583439 | 2024 | Osteoprotegerin and receptor activator of the nuclear factor kappa B ligand (RANKL) in healthy pubertal girls - relationships with physical growth and classical bone turnover markers. | 0 |
| 38594779 | 2024 | Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma. | 0 |
| 38614129 | 2024 | Accumulation of γδT cells in the decidua is promoted by RANKL which upregulates ICAM-1 via NF-κB. | 0 |
| 35726900 | 2023 | RANKL interferes with osteoclastogenesis in PEG-fused U937 cells through LGR4. | 0 |
| 36251145 | 2023 | NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma. | 1 |
| 36473204 | 2023 | RANKL and RANK in Cancer Therapy. | 1 |
| 36482064 | 2023 | Exosomal lncRNA HOTAIR promotes osteoclast differentiation by targeting TGF-β/PTHrP/RANKL pathway. | 6 |
| 36513810 | 2023 | RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts. | 8 |
| 36535121 | 2023 | Assessment of RANK/RANK-L prevalence and clinical significance in NSCLC European Thoracic Oncology Platform Lungscape cohort and SPLENDOUR randomized clinical trial. | 0 |
| 36652988 | 2023 | Expression of RANKL in breast cancer tissue in patients with fibrous dysplasia/McCune-Albright syndrome. | 0 |
Citation
Dessen P
TNFSF11 (TNF superfamily member 11)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/42633/tnfsf11
