TNFSF14 (TNF superfamily member 14)

2003-06-01 Affiliation

Identity

HGNC

TNFSF14

LOCATION

19p13.3

LOCUSID

8740

ALIAS

CD258,HVEML,LIGHT,LTg

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8740
MIM: 604520
HGNC: 11930
Ensembl: ENSG00000125735

Variants:

dbSNP: 8740
ClinVar: 8740
TCGA: ENSG00000125735
COSMIC: TNFSF14

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000125735	ENST00000245912	O43557
ENSG00000125735	ENST00000599359	O43557

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
NF-kappa B signaling pathway	KEGG	hsa04064
NF-kappa B signaling pathway	KEGG	ko04064
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	REACTOME	R-HSA-5676594
TNFs bind their physiological receptors	REACTOME	R-HSA-5669034

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
11714797	2001	Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction.	65
16934497	2006	Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure.	53
17652173	2007	Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth.	43
20826693	2010	Herpes simplex virus glycoprotein D interferes with binding of herpesvirus entry mediator to its ligands through downregulation and direct competition.	33
18292573	2008	Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells.	31
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
15944326	2005	The critical role of LIGHT in promoting intestinal inflammation and Crohn's disease.	26
16861346	2006	Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes.	24
15634882	2005	LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling.	22
15634882	2005	LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling.	22

Citation

Dessen P

TNFSF14 (TNF superfamily member 14)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42637/tnfsf14-(tnf-superfamily-member-14)