TNFSF8 (TNF superfamily member 8)

2003-06-01  

Identity

HGNC
TNFSF8
LOCATION
9q32
LOCUSID
944
ALIAS
CD153,CD30L,CD30LG,TNLG3A

Other Information

Locus ID:

NCBI: 944
MIM: 603875
HGNC: 11938
Ensembl: ENSG00000106952

Variants:

dbSNP: 944
ClinVar: 944
TCGA: ENSG00000106952
COSMIC: TNFSF8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106952ENST00000223795P32971
ENSG00000106952ENST00000223795Q52M88
ENSG00000106952ENST00000618336A0A087X228

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

References

Pubmed IDYearTitleCitations
363013682023Several genetic variants associated with systemic sclerosis in a Chinese Han population.1
363013682023Several genetic variants associated with systemic sclerosis in a Chinese Han population.1
302020162018Host resistance to pulmonary Mycobacterium tuberculosis infection requires CD153 expression.37
302020162018Host resistance to pulmonary Mycobacterium tuberculosis infection requires CD153 expression.37
271055212016CD30 on extracellular vesicles from malignant Hodgkin cells supports damaging of CD30 ligand-expressing bystander cells with Brentuximab-Vedotin, in vitro.27
271055212016CD30 on extracellular vesicles from malignant Hodgkin cells supports damaging of CD30 ligand-expressing bystander cells with Brentuximab-Vedotin, in vitro.27
253202852015Association of TNFSF8 regulatory variants with excessive inflammatory responses but not leprosy per se.21
253202852015Association of TNFSF8 regulatory variants with excessive inflammatory responses but not leprosy per se.21
244478652014In rheumatoid arthritis soluble CD30 ligand is present at high levels and induces apoptosis of CD30(+)T cells.8
246763582014IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.7
250590652014[Soluble apoptosis markers in obese patients with food intolerance].0
244478652014In rheumatoid arthritis soluble CD30 ligand is present at high levels and induces apoptosis of CD30(+)T cells.8
246763582014IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.7
250590652014[Soluble apoptosis markers in obese patients with food intolerance].0
226283042012A novel role for reciprocal CD30-CD30L signaling in the cross-talk between natural killer and dendritic cells.7

Citation

Dessen P

TNFSF8 (TNF superfamily member 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42644