TOB2 (transducer of ERBB2, 2)

2003-02-01 Affiliation

Identity

HGNC

TOB2

LOCATION

22q13.2

LOCUSID

10766

ALIAS

APRO5,TOB4,TOBL,TROB2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10766
MIM: 607396
HGNC: 11980
Ensembl: ENSG00000183864

Variants:

dbSNP: 10766
ClinVar: 10766
TCGA: ENSG00000183864
COSMIC: TOB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000183864	ENST00000327492	Q14106
ENSG00000183864	ENST00000434408	B0QXZ4

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA degradation	KEGG	ko03018
RNA degradation	KEGG	hsa03018

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
32404348	2020	Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation.	9
32619704	2020	MiR-375 promotes human periodontal ligament stem cells proliferation and osteogenic differentiation by targeting transducer of ERBB2, 2.	2
32404348	2020	Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation.	9
32619704	2020	MiR-375 promotes human periodontal ligament stem cells proliferation and osteogenic differentiation by targeting transducer of ERBB2, 2.	2
25649327	2015	Upregulation of miR-362-3p Modulates Proliferation and Anchorage-Independent Growth by Directly Targeting Tob2 in Hepatocellular Carcinoma.	26
25649327	2015	Upregulation of miR-362-3p Modulates Proliferation and Anchorage-Independent Growth by Directly Targeting Tob2 in Hepatocellular Carcinoma.	26
22252318	2012	Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities.	28
22252318	2012	Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities.	28
21242960	2011	Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation.	40
21242960	2011	Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation.	40
19760502	2010	Transactivation of ErbB-2 induced by tumor necrosis factor alpha promotes NF-kappaB activation and breast cancer cell proliferation.	19
19940862	2010	Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy.	0
19760502	2010	Transactivation of ErbB-2 induced by tumor necrosis factor alpha promotes NF-kappaB activation and breast cancer cell proliferation.	19
19940862	2010	Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy.	0
12135500	2002	Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system.	23

Citation

Dessen P

TOB2 (transducer of ERBB2, 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42652