Identity
HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
TOP2,TOP2alpha,TOPIIA,TP2A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7153
MIM: 126430
HGNC: 11989
Ensembl: ENSG00000131747
Variants:
dbSNP: 7153
ClinVar: 7153
TCGA: ENSG00000131747
COSMIC: TOP2A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000131747 | ENST00000423485 | P11388 |
| ENSG00000131747 | ENST00000577541 | J3QR57 |
| ENSG00000131747 | ENST00000581055 | J3KTB7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 29938344 | |
| PA445113 | Neutropenia | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 29938344 | |
| PA449412 | doxorubicin | Chemical | VariantAnnotation | not associated | PD | 29938344 | |
| PA449476 | epirubicin | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38205938 | 2024 | HPV16 E6 promoting cervical cancer progression through down-regulation of miR-320a to increase TOP2A expression. | 2 |
| 38287116 | 2024 | Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis. | 2 |
| 38403725 | 2024 | Activating the abscission checkpoint: Top2α senses chromatin bridges in cytokinesis: Top2α binds to DNA knots on chromatin bridges to activate the abscission checkpoint in human cells. | 0 |
| 38445610 | 2024 | TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation. | 0 |
| 38561479 | 2024 | The correlation study between TOP2A gene expression in circulating tumor cells and chemotherapeutic drug resistance of patients with breast cancer. | 0 |
| 38806610 | 2024 | Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer. | 0 |
| 38205938 | 2024 | HPV16 E6 promoting cervical cancer progression through down-regulation of miR-320a to increase TOP2A expression. | 2 |
| 38287116 | 2024 | Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis. | 2 |
| 38403725 | 2024 | Activating the abscission checkpoint: Top2α senses chromatin bridges in cytokinesis: Top2α binds to DNA knots on chromatin bridges to activate the abscission checkpoint in human cells. | 0 |
| 38445610 | 2024 | TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation. | 0 |
| 38561479 | 2024 | The correlation study between TOP2A gene expression in circulating tumor cells and chemotherapeutic drug resistance of patients with breast cancer. | 0 |
| 38806610 | 2024 | Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer. | 0 |
| 36656469 | 2023 | TOP2A Expression in Pheochromocytoma and Abdominal Paraganglioma: a Marker of Poor Clinical Outcome? | 0 |
| 37114547 | 2023 | Prognostic Significance of DNA Topoisomerase II Alpha (TOP2A) in Cholangiocarcinoma. | 0 |
| 37172528 | 2023 | The clinicopathological significance of TOP2A expression in malignant peritoneal mesothelioma. | 1 |
Citation
Dessen P
TOP2A (DNA topoisomerase II alpha)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42659/top2a
