TOP2B (DNA topoisomerase II beta)

2003-06-01  

Identity

HGNC
TOP2B
LOCATION
3p24.2
LOCUSID
7155
ALIAS
TOPIIB,top2beta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7155
MIM: 126431
HGNC: 11990
Ensembl: ENSG00000077097

Variants:

dbSNP: 7155
ClinVar: 7155
TCGA: ENSG00000077097
COSMIC: TOP2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077097ENST00000264331Q02880
ENSG00000077097ENST00000413971H7BZ82
ENSG00000077097ENST00000424225E9PCY5
ENSG00000077097ENST00000435706Q02880

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA replication proteinsREACTOMER-HSA-4615885
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449259dexrazoxaneChemicalPathwayassociated21048526
PA449412doxorubicinChemicalPathwayassociated21048526

References

Pubmed IDYearTitleCitations
380382602024Using energy to go downhill-a genoprotective role for ATPase activity in DNA topoisomerase II.3
382403442024DNA-PKcs-mediated transcriptional regulation of TOP2B drives chemoresistance in acute myeloid leukemia.0
382632552024MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner.0
380382602024Using energy to go downhill-a genoprotective role for ATPase activity in DNA topoisomerase II.3
382403442024DNA-PKcs-mediated transcriptional regulation of TOP2B drives chemoresistance in acute myeloid leukemia.0
382632552024MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner.0
364107932023Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIβ Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide.2
367667052023Taspase1 Facilitates Topoisomerase IIβ-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription.1
370687672023Revisiting TOP2B-related phenotypes: Three new cases and literature review.0
378342532023To Break or Not to Break: The Role of TOP2B in Transcription.3
364107932023Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIβ Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide.2
367667052023Taspase1 Facilitates Topoisomerase IIβ-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription.1
370687672023Revisiting TOP2B-related phenotypes: Three new cases and literature review.0
378342532023To Break or Not to Break: The Role of TOP2B in Transcription.3
356601582022A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.5

Citation

Dessen P

TOP2B (DNA topoisomerase II beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42660